Abstract

Context: Ectopic pregnancy is defined as any pregnancy in which fertilized ovum implants outside the uterus. Commonest site is fallopian tubes (90–95%), majority in the ampulla or isthmic portions and the major cause of maternal mortality and morbidity in first trimester of pregnancy. Aims: To study the histopathological changes in fallopian tube in ectopic pregnancy and correlate the changes with age group, parity and to recognise the pre disposing risk factors such as acute and chronic salpingitis, salpingitis isthmica nodosa, granulomas and other related findings. Settings and Design: This study was conducted on resected specimens of fallopian tube/tubal mass of ectopic pregnancy received in the department of pathology, B.R.D. Medical College, Gorakhpur. Methods and Material: Each fallopian tube was inspected grossly for products of conception and length was noted and sectioned at 3-5 mm intervals and fixed in 10% formalin. Sections were stained with H & E stain and examined microscopically. Statistical analysis used: Prospective cross-sectional Results: Total 100 cases were studied, 98% were of tubal ectopic in which ampullary in 66.33% cases. Age of patients ranged from 19-44 years with mean age 24.4 years. Maximum 69% cases were of 21-30 years, 59% of rural areas, 76% Hindu, 56% of low socio-economic status, 31% with parity two, 69.18% involve right tube, 60.2% were ruptured tube. Commonest trophoblastic infiltration was stage III (38.8%). Conclusions: Histopathology plays a crucial role in confirming ectopic pregnancy and identification of risk factors. Commonest risk factors were pelvic inflammatory disease in 28% and abortion in 10% cases. Chronic salpingitis was in 46.05% and acute salpingitis in 23.68% cases. Key Messages: Histopathology plays a crucial role in confirming ectopic pregnancy and identification of risk factors. Early diagnosis of ectopic pregnancy can prevent rupture and unruptured ectopic pregnancy can be treated conservatively.

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