Abstract

Context: In this study, we have analyzed the spectrum of Neuronal and mixed Neuronal-Glial tumours and their incidence, age distribution, gender distribution and site of occurrence at a Government tertiary care hospital over a period of six years. Aims: To assess the spectrum and prognosis of Neuronal and mixed Neuronal-Glial tumours and to review the slides from 2014 in accordance with the recent classification. Materials and Methods: This study includes cases from over a period of six years from 2014-2019, analyzed both retrospectively and prospectively. The slides were reviewed in accordance with the recent classification. Results: We identified 38 cases, which included 11 cases of Central Neurocytoma, 10 cases of Ganglioglioma, 10 cases of DysembryoplasticNeuroepithelial tumour, 3 cases of Anaplastic ganglioglioma, 3 cases of Papillary glioneuronal tumour and 1 case of Paraganglioma. 24 cases were WHO grade I, 11 cases grade II and 3 casesgrade III.Central Neurocytoma predominantly occurred in the age group 20–30 and commonly affected males. The commonest site was intraventricular region. Ganglioglioma predominantly occurred in the age group 30-50 and males and females were equally affected. The commonest site involved was fronto-temporal region. DysembryoplasticNeuroepithelial tumour occurred predominantly in the age group 10-20 years and commonly affected males. The commonest site was frontal region.Among the three cases of Papillary glioneuronal tumour, which are usually low grade neoplasms, one case presented with recurrence. Conclusion: The present study helps in gaining experience in the clinical and histological profile of these diverse tumours. Keymessages: A case of papillary glioneuronal tumour presented with recurrence which emphasizes the need for molecular profiling of these neoplasms for better understanding.

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