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A Histomorphological Study of Abnormal Uterine Bleeding

K.P. Karumbaiah, Associate Professor, Dept. of Pathology, Kodagu Institute of Medical Sciences, Madikeri, Karnataka 571201, India. , Karumbaiah K.P.* , Dhanalaxmi D.P.**

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Indian Journal of Pathology: Research and Practice 6(3(part-1)):p 563-568, Jul-Sep 2017. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6317.10

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Abstract

The study is a prospective study undertaken on endometrial curettings from clinically diagnosed cases of abnormal uterine bleeding (AUB). The objectives were to analyze the histomorhological patterns of endometrium in clinically diagnosed cases of AUB in different age groups in comparison with the other similar studies. Patients from all the age groups were included in the study and all types of pregnancy complications were excluded from the study. The endometrial biopsy material, fixed in 10% formalin was processed, sections were cut from blocks prepared from paraffin, stained with H&E and studied. A total of 100 endometrial biopsies from clinically diagnosed AUB patients were studied histopathologically. Out of these 46% were simple hyperplasia, 22% were proliferative endometrium, 9% were complex hyperplasia, 8%were secretory phase, disordered proliferative endometrium and endometrial polyp were 4% each, anovulatory endometrium and adenocarcinoma were 2% each, chronic endometritis , inadequate secretory phase and pillendometrium were 1% each. Majority of the patients in the present study were in the age groups of 4150yrs. Most common presenting complaint in the present study was menorrhagia. In conclusion it is observed that AUB is most common in perimenopausal age groups with histomorphological pattern of simple hyperplasia, followed by normal proliferative pattern, secretory pattern and endometrial carcinoma is seen in older age groups and most commonly presenting with post menopausal bleeding. Histopathological findings in the endometrial biopsies of these patients help to detect & differentiate between functional causes and organic lesions there by facilitating appropriate patient management.

Keywords: Abnormal Uterine Bleeding; Simple Hyperplasia; Menorrhagia.

  

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6317.10

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