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A Clinical Study to Prove the Better Efficacy of Tinidazole over Metronidazole for the Treatment of Amoebic Liver Abscess

Nandyala Penchala Reddy, PG Resident, Department of General Surgery, PES Medical College, Kuppam, Andhra Pradesh 517425, India. , M. Balachandar1 , Nandyala Penchala Reddy2

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New Indian Journal of Surgery 9(5):p 662-664, Sep-Oct 2018. | DOI: DOI: https://dx.doi.org/10.21088/nijs.0976.4747.9518.23

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Abstract

The Efficacy of Metronidazole and Tinidazole has been compared in 18 patients with Amoebic Liver Abscess. Only those with unequivocal clinical,radiological and laboratory evidence of Amoebic Liver Abscess were included; diagnostic and therapeutic aspiration was performed where necessary. This study was conducted in department of general surgery at PES Medical College, Kuppam in the period of September 2017 to May 2018 over a study population of 18 patients. 9 patients received metronidazole and 9 patients received tinidazole in random order. The 2 groups were compared for the efficacy of drugs. Both drugs were given Intravenously (that is, metronidazole 500mg TID and tinidazole 800mg BID) and intra cavity instillation ( If needed, both once daily) for a minimum of 3 days. With treatment extended if considered clinically advisable. 5 of 9 patients (55.56%) were cured with metronidazole given for an average period of 7 days (range 4 to 14 days). 8 of 9 patients (88.89%) given tinidazole were cured and the mean duration of treatment was 4 days (range 3 to 6 days). There were fewer side-effects with tinidazole. Tinidazole was found to be superior to metronidazole in overall efficacy because a shorter course of treatment was necessary and it caused fewer side-effects.

Keywords: Metronidazole; Tinidazole; Amoebic Liver Abscess.  

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DOI: DOI: https://dx.doi.org/10.21088/nijs.0976.4747.9518.23

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