Efficacy and Safety of Seraseal as a Hemostatic and Dural Sealing Agent in Trauma & Emergency Surgery: A Prospective Post-Marketing Observational Study

Ajaypal Randhawa , Avinash Melkote , Priyanka D S , Saveen Kumar S , Baburao Vikram

Published Online : 2025-07-30

Background: Intraoperative bleeding and cerebrospinal fluid (CSF) leakage are critical challenges in trauma and emergency neurospinal procedures. Failure to achieve watertight dural closure can result in postoperative complications, prolonged recovery, and increased healthcare costs. SeraSeal (3000 IU/mL) is a novel topical hemostatic agent formulated with agar and bovine-derived clotting factors, designed to achieve rapid emostasis and effective dura sealing. This study aimed to evaluate the real-world efficacy and safety of SeraSeal in trauma and emergency cranial/spinal surgeries. Method: A prospective, single-center, post-marketing observational study was conducted among 50 patients undergoing brain, spine, or general surgery with active bleeding. SeraSeal was applied topically, and hemostatic outcomes were evaluated at 1, 4, 7, and 10 minutes post-application. Primary endpoints included time to hemostasis, CSF leak incidence, and blood loss volume. Secondary outcomes assessed included rebleeding, surgeon satisfaction, and adverse events. Results: Of the 50 patients, 100% success rate of watertight dural sealing without intraoperative CSF leak or complications. Postoperative CSF leak was observed in only 4 patients (8%), with an overall average leak incidence of 1% per patient. Blood loss significantly reduced from baseline (mean 71.22 mL) to 21.04 mL at 10 minutes post-application (p < 0.001). Mean time to hemostasis also significantly decreased from 24.32 seconds to 8.98 seconds (p < 0.001). Surgeon satisfaction improved significantly over time (p = 0.007), and no adverse drug-related events were reported. Conclusion: This study suggests that SeraSeal is an effective and safe primary haemostatic and dura sealant agent, offering rapid watertight dura sealing, bleeding control, minimal blood loss, and a favourable safety profile.

Original Article English P. 59-69

Predicting the Impact of Viral Infections on Neuronal Aging and Cognitive Decline Using AI-Based Brain Transcriptomics

Prachi Srivastava , Amaan Arif

Published Online : 2025-07-30

Neuronal aging is a complex process characterized by cognitive decline and susceptibility to neurodegenerative diseases, including AD, MS, and PD. As individuals age, brain undergoes structural and functional alterations, leading to impaired synaptic plasticity, neuroinflammation, and oxidative stress. Additionally, aging weakens immune response, ultimately CNS more vulnerable to latent viral infections and reactivations. HSV-1 and EBV have been strongly implicated in neurodegenerative pathologies. HSV-1, a neurotropic virus, has been found in postmortem brains of AD patients, suggesting a role in amyloidbeta accumulation and chronic uroinflammation. Similarly, EBV has been linked to MS, with viral reactivation triggering inflammatory cascades that contribute to demyelination and neurodegeneration. Other viruses, including CMV, HIV, and SARS-CoV-2, have also been associated with long-term neurological complications, worsening cognitive decline in aging individuals. By integrating deep learning and machine learning approaches, AI can predict disease progression, assess individual susceptibility to viral-induced neurodegeneration, and aid in early diagnosis. Brain transcriptomics, which involves RNA sequencing and gene expression profiling, provides insights into molecular pathways disrupted by viral infections. These technologies enhance our ability to identify biomarkers for neurodegenerative diseases, paving the way for targeted interventions. This study highlights the intersection of viral neuropathology, aging, and AI-based transcriptomics, emphasizing the need for computational tools to unravel the complexities of neurodegeneration. Understanding viral contributions to neuronal aging can lead to innovative therapeutic strategies, potentially mitigating the impact of chronic viral infections on cognitive health. As AI continues to evolve, its integration with

Review Article English P. 70-79