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Unfolding the Impact of Artificial Sweetners on Gut Microbiome Leading to Metabolic Disease: Obesity & Diabetes Mellitus

Nancy Sahni, Urvashi Rana

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International Journal of Food, Nutrition & Dietetics 12(3):p 154-162, September - December 2024. | DOI: https://doi.org/10.21088/ijfnd.2322.0775.12324.7

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Nancy Sahni, Urvashi Rana, Unfolding the Impact of Artificial Sweetners on Gut Microbiome Leading to Metabolic Disease: Obesity & Diabetes Mellitus. Int J Food Nutr Diet. 2024;12(3):154-162.

Timeline

Received : November 30, 2024         Accepted : December 10, 2024          Published : December 30, 2024

Abstract

Artificial sweeteners (AS) are in high demand due to their low-calorie content. They are used as sugar substitutes by diabetic and obese people, however current research indicates that NSS use may contribute to metabolic disorders. The FSSAI has cleared the use of six artificial sweeteners within acceptable amounts to improve tolerance and ensure safe use. However, many popular nutraceuticals and protein powders contain artificial sweeteners without mentioning how much are used, which may exceed the FSSAI’s limits at the expense of the consumer’s health.The health effects of these non-caloric sweeteners are still debated since they are metabolized differently, and their metabolic end products have been connected to gut microbiota, glucose intolerance, and weight gain. Although long-term human studies on artificial sweeteners are rare, an effort has been made to analyse previous evidence to consolidate the relation of AS with health issues.


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Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.


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Cite this article

Nancy Sahni, Urvashi Rana, Unfolding the Impact of Artificial Sweetners on Gut Microbiome Leading to Metabolic Disease: Obesity & Diabetes Mellitus. Int J Food Nutr Diet. 2024;12(3):154-162.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


Received Accepted Published
November 30, 2024 December 10, 2024 December 30, 2024

DOI: https://doi.org/10.21088/ijfnd.2322.0775.12324.7

Keywords

Artificial sweetenersDysbiosisGut microbiomeDiabetes and metabolic diseases

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Received November 30, 2024
Accepted December 10, 2024
Published December 30, 2024

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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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