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Term PROM : Induction of Labour By Dinoprostone Followed by Oxytocin Versus Oxytocin Alone

Divya Jyoti Singh Juneja, Senior Resident, Department of Obstetrics & Gynaecology, Chittaranjan Seva Sadan College of Obstetrics & Gynaecology, Kolkata, West Bengal, 700025, India , Divya Jyoti Singh1 , Pranab Kumar Biswas2 , Sanjay Mazumder3 , Sabyasachi Sarkar4 , Sajal Datta5 , Narayan Jana6

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Indian Journal of Obstetrics and Gynecology 6(5):p 469-473, Sep-Oct 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6518.5

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Abstract

 Context: Pre labour rupture of  membrane (PROM) is a common event in obstetrics.There is still controversy regarding the best method of induction of labour. So purpose of this study is to verify the efficacy and safety in between the two methods of induction i.e. oxytocin alone or dinoprostone followed by oxytocin. Aims: Comparison of efficacy of oxytocin versus dinoprostone gel followed by oxytocin for induction of labour in PROM in terms of induction delivery interval, mode of delivery and maternal & fetal outcome. Settings and Design: This study was carried out at a tertiary care hospital. Admitted women from the labour ward and obstetric wards were enrolled in the study after taking written informed consent. Material and Methods: Randomized control study in a tertiary care hospital and referral centre for one year. Two hundred women randomly allocated to study group A & control group B after fulfilling inclusion/ exclusion criteria. Group A patients were induced with dinoprostone gel  0.5 gm followed by oxytocin six hours later. Group B patients were induced with oxytocin alone. Results: There was no difference in mean induction to delivery interval of both groups. Proportion of vaginal delivery in Group A was significantly higher than that of   Group B because of higher proportion of failed induction and non progress of labour in later. There was no significant difference in maternal and fetal outcome in both the groups. Conclusion: Study showed that use of sustained released dinoprostone followed by oxytocin for induction of labour in term PROM led to a significantly higher proportion of women with vaginal delivery within 24 hours of induction, and a small proportion of women who required cesarean section compared with the use of oxytocin alone.

Keywords: Premature Rupture of Membrane (PROM); Oxytocin; Dinoprostone.  

 

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6518.5

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