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Synthesis and Biological Evaluation of Dithiocarbamates of 1-Naphylamine Chalchone

K. Madhavi, Assistant Professor, Department of Pharmaceutical Chemistry, V.V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh 521356, India. , K. Madhavi1 , A. Lakshmana Rao2 , K. Jaya Bharathi3 , J. Subhashini4 , K. Bindu Bhargavi5 , K. Anjaneyulu6

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Journal of Pharmaceutical and Medicinal Chemistry 4(1):p 11-16, Jan-June 2018. | DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.4118.2

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Abstract

The new dithio carbamate derivatives, 2- (naphthalen-8-ylcarbamoyl)-1-(4-hydroxyphenyl) ethyl diethylcarbamodithioate (IIIa) and 2- (naphthalen-8-ylcarbamoyl)-1-(2,4-dichlorophenyl) ethyl diethylcarbamodithioate (IIIa) were synthesized from 1-naphylamine chalchone. The new molecules were characterized by spectral and elemental analysis data. The synthesized analogues ere evaluated for anti-mitotic activity by Bengal gram seed germination model showed strong to moderate activities compared with control. Both the molecules showed good inhibition.

Keywords: Dithiocarbamates; 1-Naphthalamine; Antimitotic Activity.

 

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DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.4118.2

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