Home > Journals > Journal of Pharmaceutical and Medicinal Chemistry

Journal of Pharmaceutical and Medicinal Chemistry

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Antihypertensive Efficacy of Carvedilol and its Influence on Blood Glucose and Lipid Profile in Patients of Stage 1 Hypertension as Seen in a Teaching Hospital of India

Sanjay Kumar, Professor, Department of Pharmacology, GSL Medical College, Rajahmundry, Andhra Pradesh 533296, India. , Tamilisetti Vidya Sagar1 , Sanjay Kumar2 , Pramila Nayak3

Author Information

Licence:



Journal of Pharmaceutical and Medicinal Chemistry 4(1):p 5-10, Jan-June 2018. | DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.4118.1

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Objective: To investigate Antihypertensive efficacy of Carvedilol and its influence on blood glucose and lipid profile in patients of stage 1 hypertension.

Materials and Methods: Total of 60 patients were enrolled in the study, randomly allocated into two groups, group A and group B with 30 patients, group A received Metoprolol 25mg  twice daily and group B received Carvedilol 12.5mg twice daily, reduction in blood pressure compared at 12 and 24weeks, effect on fasting blood glucose and lipid profile compared at 24th week, Statistical analysis was done using paired and unpaired t test and data is presented as mean±SD.

Results: Mean SBP reduction with Carvedilol is 23±6.16 mmHg with no significant difference (p>0.05) compared to Metoprolol group (20.13±5.73), Mean DBP reduction with Carvedilol is 9.93±1.349 with no significant difference (p>0.05) compared to Metoprolol group (8.87±2.148) at 24th week of the study. Metoprolol showed a significant (p<0.05) elevation on Fasting blood sugar, Serum total cholesterol,LDL,VLDL and serum triglycerides, when compared with Carvedilol at the end of the study.

Conclusion: Result of the study shows that Carvedilol and Metoprolol are equally effective in reduction of blood pressure and Carvedilol has added advantage in less elevation of fasting blood glucose, serum total cholesterol, LDL, VLDL and serum triglycerides and which is an advantage to the hypertensive patients with lipid disorder and impaired glucose tolerance. 

Keywords: Carvedilol; Metoprolol; Lipid Profile; Hypertension; Fasting Blood Glucose.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.4118.1

Keywords


Article Level Metrics

Last Updated

Monday 07 September 2026, 23:53:27 (IST)

1018

Accesses

3
100
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share