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Study of p53 Gene Expression in Urinary Bladder Carcinoma: Prospective & Retrospective Study

Hema Pant, Professor & Head, Department of Pathology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh 243001, India. , Nidhi Sachdev* , Hema Pant**

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Indian Journal of Pathology: Research and Practice 6(3(part-1)):p 591-601, Jul-Sep 2017. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6317.14

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Abstract

Introduction: The present study of Urothelial carcinoma is intended to include: Retrospective hospital based observational study of paraffin section of old block and cases attending our hospital. Material Methods: The study is conducted in the Department of Pathology at SRMS IMS, during a period of 21 months, 1st January 201330th September 2014. Total 80 cases of Urothelial Carcinoma were included in the study. Tumour is classified according to WHO classification and all the 80 cases were subjected to Immunohistochemical study for p53 from the representative areas. Samples demonstrating at least 10% nuclear reactivity were considered positive for p53. Results: Out of 4 cases of PUNLMP, 1 case (25%) was positive for p53. Out of 27 cases of Low grade papillary urothelial carcinoma, 4 cases (14.8%) were positive for p53. Out of 48 cases of High grade papillary urothelial carcinoma, 28 cases (58.3%) were positive for p53. 1 case of Mucinous adenocarcinoma with signet ring change was positive for p53. Discussion: The present study results were in consistency with the other studies, i.e a higher rate of p53 protein positive staining was seen in high grade tumor. Conclusions: p53 alterations are significantly associated to clinicopathological features of poor prognosis, the inclusion of p53 mutation status into a predictive panel of tumor markers for bladder cancer is recommended.

Keywords: p53; Urinary Bladder Carcinoma; IHC.

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6317.14

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