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Study of Feto-Maternal Outcome in Pregnant Females with Infective Hepatitis

Vishal J. Patel, Resident Doctor Dept. of Obstetrics and Gynecology, Government Medical College & New Civil Hospital, Surat, Gujarat 395001, India. , Nilam Prajapati1 , Vishal Patel2 , Parul Udhanawala3 , Bhavika Gamit4

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Indian Journal of Obstetrics and Gynecology 6(2):p 155-160, Mar-Apr 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6218.13

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Abstract

Objectives: To study the clinical course, morbidity and mortality in the pregnant patients affected by the disease, To study the effect of Infective hepatitis on outcome of pregnancy. Material & Method: The present study was undertaken at New Civil Hospital, Surat. The time period was of 6 months i.e. from January 2017 to June 2017. All pregnant females having infective hepatitis were included, Pregnant females having other diseases and condition which resembles the clinical presentation of viral hepatitis were excluded. Summary: (1) Incidence of viral hepatitis in pregnant women in the present series was 1.21, (2)Total maternal mortality is 2 cases in the analysis of 50 cases i.e. mortality 4%, (3) Mortality is higher during second trimester (16.6%) as compared to first and third trimester, (4) Higher mortality in delivered patients (4.54%), (5) Fetal wastage was more in patients having viral hepatitis (6% )abortion. 10% still birth, 48% premature birth. Conclusion: Infective hepatitis is a potentially devastating disease. In pregnancy maternal morbidity and mortality is severe and the infection exerts a significantly negative effect on perinatal outcome.The early diagnosis and prompt initiation of therapy are of utmost importance in reducing the risks of serious maternal and fetal complications. In present study multigravida constituted 64% and primigravida 36% maximum cases were admitted in III trimester (34 out of 50 cases). The high rate of abortion (4/50 cases), premature labour (6/50 cases) and still birth (10/50 cases) may be due to indirect effect of disease, hypoproteinemia and excess of estrogen in circulation which sensitizes the uterus to oxytocin and prostaglandins.

Keywords: Primigravida; Hepatitis.

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6218.13

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