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Indian Journal of Pathology: Research and Practice

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Study of Biochemical Parameters in Pregnancy Induced Hypertension (PIH)

Pradeep Kumar L.* , Pradeep Kumar L.* , Harish S. Permi** , Murthy Srinivasa V.*** , Yadavalli Guruprasad****

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Indian Journal of Pathology: Research and Practice 5(2):p 191-194, May-Aug 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5216.21

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Abstract

 Hypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. Hypertension is a sign of an underlying pathology which may be preexisting or appear for the first time during pregnancy. Various Biochemical changes like increase in serum Bilirubin, serum uric acid, LDH, AST, ALT enzymes are seen. Aims and Objectives: Evaluation of Biochemical parameters like serum Bilirubin, serum uric acid, LDH, AST, ALT enzymes in PIH. To identify the early Biochemical parameters predictive of preeclampsia and HELLP (Hemolysis, Elevated Liver enzymes and Low Platelet syndrome) syndrome. Materials and Methods: A two year study from Aug 2011 to July 2013 was carried out in the Dept. of pathology ESIMC, Bangalore on 100 PIH cases. Biochemical parameters were estimated in all the cases. p values for all parameters were statistically derived and evaluated. Results: Total of 100 cases were included in the study. 37 were mild GH (Gestational Hypertension), 9 cases were severe GH, 29 cases were mild preeclampsia and 25 cases were in severe preeclampsia group. Mean value of serum uric acid, LDH and serum Bilirubin in severe preeclampsia was 6.58±5.63, 438.84±483.3 and 0.63±1.04 respectively. Raised LDH, AST, ALT enzymes were observed in severe preeclampsia with a mean value of 31.00±62.05 and 55.60±133.94 in ALT and AST respectively. Conclusion: Raised values of Biochemical parameters could prompt progression of PIH and possibility of adverse outcome. Therefore estimation of Biochemical parameters can be considered as an early, simple and rapid procedure in the assessment of severity of preeclampsia and to prevent progression to HELLP syndrome and DIC (Disseminated Intravascular Coagulation).

Keywords: Hypertension; Preeclampsia; Eclampsia; Biochemical Parameters. 

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5216.21

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