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Stability Indicating Chromatographic Method Development and Validation for the Simultaneous Estimation of Nifedipine and Lidocaine in Cream Dosage Form by HPLC

Vaishnov Ravi Sanwerlal* , Vaishnov Ravi Sanwerlal* , Chirag Jayantilal Patel** , Gali Vidya Sagar***

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Journal of Pharmaceutical and Medicinal Chemistry 2(1):p 41-47, January - June 2016. | DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.2116.5

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Abstract

 A simple, novel, rapid, precise, accurate, specific and cost effective High performance thin layer chromatographic method has been developed and validated for Simultaneous Estimation of Nifedipine and Lidocaine in Cream Dosage Form. The Stationary Phase used was C18Hypersil BDS column and the Mobile Phase used was Mixture of Buffer (pH 3.0): Methanol (50:50). The Developed Method was Validated As per International Conference on Harmonization (ICH) guidelines. Calibration Curve was found to be Linear and the Correlation Coefficient was found to be 0.998 and 0.999 for Nifedipine and Lidocaine respectively. The Limit of Detection for Nifedipine and Lidocaine was found to be 0.18µg/ml and 0.59µg/ml respectively. The Limit of Quantization for Nifedipine and Lidocaine was found to be 0.55µg/ml and 1.79µg/ml respectively. The Degradation Study Preformed are Oxidative, Acidic, Basic, Thermal and Photolytic. 

Keywords: Validation; HPLC; Nifedipine; Lidocaine; Cream Dosage Form.

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DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.2116.5

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