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Hypoglycemic Effect of Dichloromethane Extract of Caeselpinia bonducella leaves in Rats with High Fructose Diet Induced Diabetes

Rachana V. Katbamna* , Rachana V. Katbamna* , Mayuri M. Thummer*

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Journal of Pharmaceutical and Medicinal Chemistry 2(1):p 35-40, January - June 2016. | DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.2116.4

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Abstract

Insulinresistance has been considered as the most important component of type 2 diabetes mellitus (DM2). Plants used infolkmedicine to treat diabetes mellitusre present aviable alternative forthe control ofthis disease. This study was aimed to examine the antidiabetic effects of dichlorome thane extract of Caesalpinia bonducella in an animal model of DM2. Diabetes was induced in male Wistarrats (6-8 week sold) by feeding 21% fructose in drinking water for 8 weeks. They were treated with dichlorome thane extract of leaves of Caesalpinia bonducella (DCM 200, DCM 400) for 2 weeks. After diabetes induction and the last day of the experiment, body weight, fasting blood glucose, plasmainsulin, urinevolume and urine glucose were assayed. Blood glucose, plasmainsulin, urine gluco sean durin evolume were in creased significantly after 8 weeks of high fructose feeding (P<0.005); DCM 200 reduced body weight, plasma insulin andurineglucose (p<0.05)and no significant difference in blood glucose and urine volue. While DCM 400 significantly decreasedblood glucose (p<0.05), urineglucose (p<0.01) and plasma insulin (p<0.01), body weight (p<0.05)andurine volume (p<0.05) when compared with that of 8th week values. The study showed hypoglycemia effects and improvement of insulin resistance of dichloromethane extract of leaves of Caeslpinia bonducella. These result scan bee xtra polated to human sand these extracts might be useful in the treatment of insulin resistance. 

Keywords: Hypoglycemia; Insulin Resistance; Fructose; Caesalpenia bonducella.

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DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.2116.4

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