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Significance of Nuclear Morphometry in Evaluation of Squamous Intraepithelial Lesions in Vaginal Cytology: A Case Series Study

B. Pushpa , Vedamoorthy Ravishankar1 , B. Pushpa

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Indian Journal of Pathology: Research and Practice 8(3):p 317-323, May-June 2019. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.8319.10

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Vedamoorthy Ravishankar, B. Pushpa. Significance of Nuclear Morphometry in Evaluation of Squamous Intraepithelial Lesions in Vaginal Cytology: A Case Series Study. Indian J Pathol Res Pract. 2019;8(3):317-323.


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Abstract

Context: Cervical cancer is the second leading malignancy in the women occurring worldwide. Researches based on nuclear morphometry on cervicovaginal smears are very much sparse; hence we have taken up this study. Aims: To valuate the role of nuclear morphometric parameters (nuclear radius and area) in differentiation of premalignant lesions of cervix. Settings and Design: Retrospective analysis of nuclear morphometric parameters in cervical smears of 40 cases. Methods and Material: Retrospective analysis of nuclear morphometric parameters in 40 cervical smears (20- LSIL and 20- HSIL) done at Government Kilpauk Medical College. Statistical analysis used: Independent sample t test was used for comparing radius and nuclear area in LSIL and HSIL lesions. Results: There was an appreciable difference in the area of nucleus among the premalignant lesions. The mean nuclear area in LSIL was 109 ± 7.446 um2 and HSIL was 132.48 ± 11.388 um2. Radius of the nucleus also showed appreciable difference in LSIL and HSIL cases included in our study. The mean nuclear radius in LSIL lesions was 3.78 ± 0.25 um and in HSIL lesions was 4.37 ± 0.34 um. Conclusions: Nuclear morphometry is henceforth an useful and dependable investigative tool in the differentiation of premalignant cervical lesions.

Keywords: Nuclear morphometry; LSIL,HSIL.


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Vedamoorthy Ravishankar, B. Pushpa. Significance of Nuclear Morphometry in Evaluation of Squamous Intraepithelial Lesions in Vaginal Cytology: A Case Series Study. Indian J Pathol Res Pract. 2019;8(3):317-323.


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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.8319.10

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