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Serum CA125, CEA, CA125/CEA ratio and LDH levels in Ovarian Cancer

Garg Nita, Professor & Head, Dept. Biochemistry, Shri Guru Ram Rai Institute of Medical & Health Sciences, Patel Nagar, Dehradun, Uttarakhand 248001, India. , Manish Abhinav1 , Garg Nita2 , Sharma Narotam3 , Gupta Ishita4

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Indian Journal of Genetics and Molecular Research 7(1):p 17-20, January- June 2018. | DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.7118.3

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Abstract

 Aim: To evaluate the diagnostic utility of Serum Cancer Antigen-125 (CA125) and Carcino embryonic antigen (CEA) and LDH levels in patients suffering from Ovarian Cancer.  

Study Design: A hospital based cross sectional study was conducted on patients attending the Out Patient Department of Gynecology of SGRR Medical College Dehradun (Uttarakhand) during a period of 8 months from June 2017 to January 2018. A total number of 70 cases of ovarian cancer etween the age group 15-75years were selected randomly for the study. 

Inclusion criteria: all patients underwent a tertiary transabdominal and transvaginal sonography and 70 cases of ovarian cancer were selected for the study.

Exclusion criteria: was age less than 15 years and more than 75 years, pregnant women, other Gynecological malignancies, TB, Diabetic Mellitus etc. 

Methodology: All the selected cases of ovarian cancer were subjected to clinical chemistry analysis of serum CA 125, CEA & LDH which was performed on fully automated analyzer 5600 of Orthoclinical Diagnostics.

Result: The serum levels of CA125, CEA and LDH were found to be very high along with a high CA125/CEA ratio. Conclusion: Our results show the importance of CA125, CEA, CA125/ CEA ratio and LDH in the diagnosis and monitoring the efficacy of treatment. Combination of serum tumour markers in the diagnosis of ovarian malignancy.

 

 

 

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DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.7118.3

Keywords

Ovarian Cancer; CA-125; CEA and LDH.

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