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Serum Beta HCG and Lipid Profile in Second Trimester as Predictors of Pregnancy Induced Hypertension

Chandralekha P.* , Chandralekha P.* , Dharma Reddy D. B.** , Sapna I. S.**

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Indian Journal of Obstetrics and Gynecology 3(2):p 73-78, July - December 2015. | DOI: DOI: https://dx.doi.org/10.21088/ijog.2321.1636.3215.3

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Abstract

 bhCG and lipid levels during second trimester of pregnancy are associated with the development of pregnancy induced hypertension (PIH). Methods: 100 pregnant women between 14-20 weeks gestation with singleton pregnancy irrespective of parity were selected randomly and serum bhCG and lipid profile were estimated by chemiluminescent immunometric assay (CLIA ) and enzymatic colorimetric test respectively. Regular follow up of the cases was done till delivery. Results were analyzed statistically. Results: Out of 93 cases followed up till delivery, 10 cases developed PIH. Serum bhCG (median ³ 35000 mIU/dl) has sensitivity of 80%, specificity of 59% and accuracy of 61%. Dyslipidemia especially LDL > 117 mg/dl had higher sensitivity (80%) but specificity and accuracy was similar to total cholesterol   (³200mg/dl) and triglycerides (156mg/dl). Serum bhCG seems to be a more efficient marker in predicting PIH at second trimester. Conclusion: The present study indicates an increased risk of PIH in patients with elevated bhCG and dyslipidemia, especially elevated cholesterol and LDL in second trimester. As yet there is no practical, acceptable and reliable screening test for PIH, Serum bhCG seems to be a very good noninvasive early predictor for the development of PIH.

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DOI: DOI: https://dx.doi.org/10.21088/ijog.2321.1636.3215.3

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