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Indian Journal of Obstetrics and Gynecology

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Role of Urinary Calcium and Urinary Calcium to Creatinine Ratio (CCR) in Diagnosis of Hypertensive Disorders of Pregnancy

Priya Sharma** , Shikha Seth* , Priya Sharma** , Alpana Rajput*** , Sushil Shukla****

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Indian Journal of Obstetrics and Gynecology 4(3):p 247-252, Sept - Dec 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.4316.8

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Abstract

  pregnancy continue to be a major cause of maternal and perinatal morbidity and mortality worldwide. Several researchers have demonstrated the role of decreasing urinary calcium and urinary calcium to creatinine ratio in the prediction and detection of preeclampsia but no clear cutoff values have been provided, so this study was palnned to determine the role of these tests planned in the early diagnosis and their feasibility as screening tools to identify women at risk of developing preeclampsia later in rural women of western U.P. Aims: To evaluate the role of urinary calcium and calcium to creatinine ratio (CCR) for early detection of Preeclampsia in spot urine sample. Settings and Design: Cross- sectional study in tertiary health care institute Methods and Material: A crosssectional study was conducted in our department over a period of one year. Normotensive and hypertensive cases with singleton term pregnancy without other chronic medical disorder were enrolled as Group I, the controls (n=48) and Group II (n=129) respectively. After workup Midstream clean catch urine sample was collected for the estimation of calcium and creatinine. Data from all the groups were statistically analysed. Statistical analysis used: Independent T test. Results: Mean value of Urinary calcium and urinary calcium to creatinine ratio in women with hypertensive disorder of pregnancy was found to be significantly lower (p value< .001) than in normotensive women. Conclusion: Estimation of calcium and creatinine in a spot urine sample is a simple test and easily performed. It has a good diagnostic accuracy, and thus it may be adopted as a diagnostic tool for preeclampsia.

Keywords: Preeclampsia; Urinary Calcium; Urinary Calcium to Creatinine Ratio (CCR).

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.4316.8

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