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Role of Serum Levels of Inhibin A, Activin A and Leptin in Early Detection of Intrauterine Growth Restricted Pregnancy

Gupta Pratiksha* , Gupta Pratiksha* , Gelabhai Jograjiya** , Arora Sarika***

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Indian Journal of Obstetrics and Gynecology 4(2):p 155-160, May-Aug 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.4216.18

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Abstract

  Context: cross-sectional study. Aims: Estimation of the relationship of Serum levels of Inhibin A, Activin A and leptin in intrauterine growth retardation and appropriate for gestational age pregnancy Settings and Design:Cross-sectional study Total numbers of 100 pregnant women, were studied in department of Gynecology and Obstetrics in Postgraduate Institute of Medical Sciences and Research. Employee State Insurance Corporation, New Delhi. Methods: Hundred pregnant women, 50 with IUGR pregnancy were matched with 50 women with Appropriate for gestatational age (AGA ) pregnancy. Inhibin A, activin A and leptin levels were measured in two samples. First sample was obtained by venous blood drawn from maternal peripheral circulation, which was collected before delivery, and second sample was taken from the umbilical vein after delivery. Data relating to delivery (e.g. mode, birth weight, signs of intrapartum fetal distress, and Apgar scores) were recorded. Statistical Analysis Used: Karl Pearson’s correlation coefficient were calculated. Mann–Whitney U test was used for comparison between cases and controls.The data were entered into a multivariable linear regression model to allow a comparison between cases and controls subjects. Paired-Samples tTest used to compare Ultrasound (USG ) findings in cases and controls. The level of significance was set as p-value - 0.05. Results: Mean maternal inhibin A and activin A (0.57±1.50–0.08±0.04 ng/ml and 1.57±0.39– .24±0.60 ng/ml respectively) and mean fetal inhibin A and activin A (1.304±2.92–0.13±0.06 and 1.43±0.58– 1.31±0.36ng/ml respectively) concentrations were significantly higher in cases. However, a statistically significant correlation was not found between fetal leptin concentrations per kilogram of fetal weight and fetal activin A concentrations in cases (r=0.120; P>0.05). Conclusions: Inhibin A, activin A and leptin as serum markers in routine screening can detect IUGR 

Keywords: Intrauterine Growth Restriction; Appropriate for Gestational Age; Inhibin A; Activin A; Leptin.

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.4216.18

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