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Role of Low Dose Cisplatin Under Insulin Induced Hypoglycaemia in Advanced Head and Neck Cancers: A Prospective Study

Virendra Bhandari, null, Virendra Bhandari1 null, Paragi Goyal2 null, Ashar Iqbal Lodi3 null, Amresh Kumar4 null, Varun Jaiswal5 null, Rajesh Kumar Jha6 null, Ayush Jain null

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Indian Journal of Cancer Education and Research 12(1):p 13-18, January - June 2024. | DOI: https://doi.org/10.21088/ijcer.2321.9815.12124.2

How Cite This Article:

Virendra Bhandari, Paragi Goyal, Ashar Iqbal Lodi et al. Role of Low Dose Cisplatin Under Insulin Induced Hypoglycaemia in
Advanced Head and Neck Cancers: A Prospective Study. Ind J Canc Educ Res 2024;12(1):13-18.
 

Timeline

Received : January 07, 2024         Accepted : January 18, 2024          Published : January 31, 2024

Abstract

Normal cells and cancer cells can be differentiated clearly during insulin induced
hypoglycaemia because of the difference in number of insulin receptors on cell membrane as
well as the biologic response which insulin modifies. This helps in targeting the chemotherapy
drugs more specifically and effectively inside the cells. Under insulin this occurs in cancer
cells with low doses of chemotherapy drugs with lesser side effects. With this aim we did
this randomised study in advanced head and neck cancer cases comparing low doses of
cisplatin under hypoglycaemia with usual weekly dose of cisplatin along with full dose of
radiotherapy. There was 77.7% complete response and 11.1% partial response in low dose and
90% complete respone in full dose chemotherapy with minimal side effects in low dose arm
and no neurologic or cardiac toxicity was observed in hypoglycaemia arm. Thus we conclude
that the use of low dose chemotherapy is equally effective with minimum side effects when
given under hypoglycaemia.
 

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Cite this article

Virendra Bhandari, Paragi Goyal, Ashar Iqbal Lodi et al. Role of Low Dose Cisplatin Under Insulin Induced Hypoglycaemia in
Advanced Head and Neck Cancers: A Prospective Study. Ind J Canc Educ Res 2024;12(1):13-18.
 

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Received Accepted Published
January 07, 2024 January 18, 2024 January 31, 2024
DOI: https://doi.org/10.21088/ijcer.2321.9815.12124.2

Keywords

Low Dose Chemotherapy; Hypoglycaemia; Insulin; Head & Neck Cancer.

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Timeline

Received January 07, 2024
Accepted January 18, 2024
Published January 31, 2024

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