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Assessment of Survival in Patients of Various Central Nervous System Tumors who Underwent Radiation Therapy

Virendra Bhandari null, Saloni Singhal1 null, Somya Sharma2 null, Pragati Kesharwani3 null, Dipshi Agrawal4 null, Ashar Iqbal Lodi5 null, Virendra Bhandari6 null

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Indian Journal of Cancer Education and Research 12(1):p 07-12, January - June 2024. | DOI: https://doi.org/10.21088/ijcer.2321.9815.12124.1

How Cite This Article:

Saloni Singhal, Somya Sharma, Pragati Kesharwani et al. Assessment of Survival in Patients of Various Central Nervous System
Tumors who Underwent Radiation Therapy. Ind J Canc Educ Res 2024;12(1):07-12.
 

Timeline

Received : January 08, 2024         Accepted : January 27, 2024          Published : February 15, 2024

Abstract

ntroduction: Central Nervous Tumors constitute 3% of cancer cases worldwide. The
incidence of CNS tumors in India ranges from 5-10 per 100,000 population, ranking 14th among
all other tumors and accounting for 2% of malignancies. The five most frequent tumors were
astrocytoma (47.3%), Medulloblastoma (11.4%), craniopharyngioma (9.7%), ependymal tumors
(4.8%), and nerve sheath tumors (4.1%). The tumor spectrum varies among different ages and
sexes. Materials and Methods: All the patients of CNS tumours who attended the Department of
Radiation Oncology, SAMC, and PGI from October 2010 to December 2019 are included in the
study. The medical records of 238 patients were evaluated, out of which only 102 were fit for
the study as per the inclusion and exclusion criteria. 

Results: The 3-year median overall survival (OS) of 8 years and Progression Free Survival
(PFS) of 7 years, while the 5-year median OS of 9 years and PFS of 7 years is recorded.
Glioblastoma (GBM) is the most aggressive out of all histologies, with a 2-year survival of
31% and a median OS of 8 months, as per our study. We got some good results with brainstem
glioma as well, with a 2-year survival of 40% and a median OS of 18 months.
Conclusion: The survival in CNS tumours has improved widely with adjuvant concurrent
chemoradiation postoperatively, and the better the resection is done, the better the survival is
seen.
 

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Data Sharing Statement

There are no additional data available. All raw data and code are available upon request

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Cite this article

Saloni Singhal, Somya Sharma, Pragati Kesharwani et al. Assessment of Survival in Patients of Various Central Nervous System
Tumors who Underwent Radiation Therapy. Ind J Canc Educ Res 2024;12(1):07-12.
 

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Received Accepted Published
January 08, 2024 January 27, 2024 February 15, 2024
DOI: https://doi.org/10.21088/ijcer.2321.9815.12124.1

Keywords

Central Nervous System Tumors; Retrospective; Survival Analysis.

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Timeline

Received January 08, 2024
Accepted January 27, 2024
Published February 15, 2024

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