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Role of Hematological Parameters: RDW, MPV, PDW as Predictive Markers in Prevention of Complications in Uncontrolled Type 2 DM (Diabetes Mellitus)

Chaithra H , Ramesh S T1 , Chaithra H2 , Niranjana Murthy B3

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Indian Journal of Pathology: Research and Practice 9(2 (Part-1)):p 89-93, May-August 2020. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.9220.15

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Ramesh S T, Chaithra H, Niranjana Murthy B. Role of Hematological Parameters: RDW, MPV, PDW as Predictive Markers in Prevention of Complications in Uncontrolled Type 2 DM (Diabetes Mellitus). Indian J
Pathol Res Pract 2020;9(2 Part I):89–93.
 

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Aims and Objectives: To study the hematological parameters and types of anemia in type 2 uncontrolled diabetes mellitus patients. To establish the role of this parameters (RDW, MPV, PDW) as predictive markers in type 2 uncontrolled DM.Methods and Materials: This case control study includes 70 cases of type 2 diabetic patients with HbA1c levels >9.0% and 30 cases of controls with HbA1c levels <6.5% was carried out for 6 months duration. Hematological parameters like Hb , RBC count, TC, MCV, RDW, Platelet count, PDW, MPV were done in the automated cell
counter (Sysmex XN330) and peripheral smear findings were studied.
Statistical Analysis: Data cleaning and data validation was done and analysed using Statistical Package for Social Sciences (SPSS-Version 20). Results: In the study, mean age of type 2 uncontrolled diabetics was 51.79±11.14 years and controls were 56.43±11.13years. RDW-CV in uncontrolled diabetics was 15.2 (13.3–17.2) and control were 12.2 (12.3–13.90). Leucocytosis was observed in uncontrolled diabetics as 9100 (7480–11900) and it indicates infections are more common in uncontrolled diabetics. MPV was (12.00±1.09) in uncontrolled diabetics and (10.05±0.97) in controls. PDW was 11.4 (10.3–12.9) in diabetics and control was 10.8 (9.8–12.5). MPV and PDW were significantly higher in uncontrolled diabetics. Conclusion: Hematological parameters such as RDW, PDW, MPV, and Platelet count were high in patients with
type 2 uncontrolled diabetes mellitus and they represent appropriate predictive markers for vascular complication due to diabetes mellitus. Present study recommends routine and regular screening for hematological parameters in diabetic patients to initiate early prevention strategies and to reduce the morbidity related to it.

Keywords: RDW; PDW; MPV.
 

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Cite this article

Ramesh S T, Chaithra H, Niranjana Murthy B. Role of Hematological Parameters: RDW, MPV, PDW as Predictive Markers in Prevention of Complications in Uncontrolled Type 2 DM (Diabetes Mellitus). Indian J
Pathol Res Pract 2020;9(2 Part I):89–93.
 

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.9220.15

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