Abstract

L-arginine is a semi-essential amino acid that plays a critical role in various physiological processes, such as protein synthesis, wound healing, immune function, and cardiovascular regulation. The available data support the hypothesis that L-arginine or L-citrulline supplementation would be suitable for implementation in resource-constrained settings and will enhance placental vascular development and improve birth outcomes. Oligohydromnios and IUGR are pregnancy complications affecting 7 percent of pregnancies. This article explores their causes, focusing on amino acid transfer and placental function. The paradoxical effects of maternal protein supplementation are discussed, alongside the therapeutic potential of Larginine and L-citrulline in improving fetal outcomes.

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