Full Text (PDF)
Indian Journal of Preventive Medicine 11(1):p 23-25, January – June 2023. | DOI: https://doi.org/10.21088/ijpm.2321.5917.11123.2
Original Article
Role of Application of Topical Nitroglycerine in Management of Flap Surgery
Ravi Kumar Chittoria, Nishad K., Neljo Thomas, Barath Kumar Singh, Jacob Antony Chakiath
Author Information
Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Indian Journal of Preventive Medicine 11(1):p 23-25, January – June 2023. | DOI: https://doi.org/10.21088/ijpm.2321.5917.11123.2
How Cite This Article:
Nishad K., Neljo Thomas, Ravi Kumar Chittoria, et al./Role of Application of Topical Nitroglycerine in Management of Flap Surgery/Indian J Prev Med. 2023;11(1):23-25.Timeline
Received : December 13, 2022
Accepted : January 15, 2023
Published : June 30, 2023
Abstract
Flaps have been used for a long time for closure of soft tissue defects by plastic surgeons and form an important part of the surgeon’s armoury, however 2% −22% of flap procedures led to necrosis in an observational study.1 The search for an ideal intervention for ensuring flap survival still continues. Topical nitroglycerine has been found effective in prevention of flap necrosis in few studies.2-4 In this article we share our experience with prevention of flap necrosis using topical nitroglycerine.
References
- 1. Matsen CB, Mehrara B, Eaton A, et al. Skin flap necrosis after mastectomy with reconstruction: a prospective study. Ann SurgOncol 2016; 23 (1):257–64.
- 2. Gdalevitch P, Van Laeken N, Bahng S, et al. Effects of nitroglyc- erin ointment on mastectomy flap necrosis in immediate breast reconstruction: a randomized controlled trial. PlastReconstrSurg 2015; 135 (6):1530–9.
- 3. Rohrich RJ, Cherry GW, Spira M. Enhancement of skin flap survival using nitroglycerin ointment. PlastReconstrSurg 1984; 73 (6):943–8.
- 4. Yun MH, Yoon ES, Lee BIl, Park SH. The effect of low-dose ni- troglycerin ointment on skin flap necrosis in breast reconstruc- tion after skin-sparing or nipple-sparing mastectomy. Arch PlastSurg 2017; 44 (6):509–15. doi: 10.5999/aps.2017.00934.
- 5. Vargas CR, Iorio ML, Lee BT. A systematic review of top- ical vasodilators for the treatment of intraoperative va- sospasm in reconstructive microsurgery. PlastReconstrSurg 2015; 136 (2):411–22
- 6. Levin RI, Jaffe EA, Weksler BB, Tack-Goldman K. Nitroglyc- erin stimulates synthesis of prostacyclin by cultured human en- dothelial cells. J Clin Invest 1981; 67 (3):762–9.
- 7. Scheuer S, Hanna MK. Effect of nitroglycerin ointment on penile skin flap survival in hypospadias repair experimental and clinical studies. Urology 1986; 27 (5):438–40.
- 8. Aral M, Tuncer S, ¸S encan A, Elmas Ç, Ayhan S. The effect of thrombolytic, anticoagulant, and vasodilator agents on the survival of random pattern skin flap. J ReconstrMicrosurg 2015; 31 (7):487–92.
- 9. De SáJZ, de Aguiar JLA, Cruz AF, Schuler ARP, de Lima JRA, Marques OM. Efeitos da nitroglicerinatópicanaautono- mização de retalhospré-fabricadosporimplante vascular emratos. Acta Cir Bras 2012; 27 (12):905–11
- 10. Dünn GL, Brodland DG, Griego RD, Huether MJ, Fazio MJ, Zitelli JA. A single postoperative application of nitroglyc- erin ointment does not increase survival of cutaneous flaps and grafts. Dermatologic Surg 2000; 26 (5):425–7.
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
About this article
Cite this article
Nishad K., Neljo Thomas, Ravi Kumar Chittoria, et al./Role of Application of Topical Nitroglycerine in Management of Flap Surgery/Indian J Prev Med. 2023;11(1):23-25.
Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
| Received | Accepted | Published |
|---|---|---|
| December 13, 2022 | January 15, 2023 | June 30, 2023 |
DOI: https://doi.org/10.21088/ijpm.2321.5917.11123.2
Keywords
Topical nitroglycerineFlap necrosisSearch for Similar Articles
Similar Articles
- A Study of Malaria in Bhutan
- Role of Autologous Platatelet Rich Plasma in Wound Bed Preparation of Nerotising...
- Modified BG Prasad Classification of Socio-economic Status: An Important Tool fo...
- A Study on the Characteristics of Animal Bites Reported at Immunisation Clinic o...
- Prevention of Malaria
Article Level Metrics
Last UpdatedSaturday 18 July 2026, 14:24:12 (IST)
772
Accesses
3
217
00
Citations
NA
NA
NA
Download citation
Article Keywords
Keyword Highlighting
Highlight selected keywords in the article text.
Timeline
| Received | December 13, 2022 |
| Accepted | January 15, 2023 |
| Published | June 30, 2023 |
licence
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
