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Prognostic Value of CD44s Expression in Oral Squamous Cell Carcinoma

Boki Yuto , Dvijendra Nath1 , Boki Yuto2 , Pallavi Agarwal3

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Indian Journal of Pathology: Research and Practice 8(4):p 425-429, July-August 2019. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.8419.8

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Dvijendra Nath, Boki Yuto, Pallavi Agarwal. Prognostic Value of CD44s Expression in Oral Squamous Cell Carcinoma. Indian J Pathol Res Pract. 2019;8(4):425–429.

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Abstract

Introduction: Aim of the study is to assess the CD44s expression in oral squamous cell carcinoma and its correlation with various histomorphological grades of the tumor and its prognostic significance. Material and Method: 42 Cases of Oral squamous cell carcinoma were included in the study. Histological grading of tumor was done on Haematoxylin and eosin stained tissue sections. Immunohistochemical study was done with CD44s antigen Marker. The histomorphological grades of tumors were correlated with CD44s expression based on degree of intensity and distribution of CD44s immunostaining. Correlation was evaluated statistically using Yate’s Chi Square test. Result and Conclusion: The study showed decrease in the intensity of CD44s expression with increase in tumor grade. This suggests that CD44 plays an important role in cell-cell and cell-matrix interaction and helps in cell adhesion, which decreases with increasing cancer stage. Thus it can be concluded that CD44s expression can be useful in evaluating the tumor progression and be of value in predicting the prognosis of the disease.

Keywords: CD44s; Oral squamous cell carcinoma; Cell adhesion.

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Dvijendra Nath, Boki Yuto, Pallavi Agarwal. Prognostic Value of CD44s Expression in Oral Squamous Cell Carcinoma. Indian J Pathol Res Pract. 2019;8(4):425–429.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.8419.8

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