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Profile of Non-Laboratory Based Vascular Age Across the Spectrum of Coronary Artery Disease

Rama Mohan Pathapati Associate Professor, Dept. of Pharmacology, Narayan Medical College and Hospital Nellore, Andhra Pradesh 524003, India. , Bhakthavatsala Reddy Chirra* , Rama Mohan Pathapati**

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Journal of Cardiovascular Medicine and Surgery 3(2):p 110-113, Jul-Dec 2017. | DOI: http://dx.doi.org/10.21088/jcms.2454.7123.3217.5

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Abstract

Introduction: Biological age is unlike from chronological age. Presence of risk factors such as age, obesity, hypertension and diabetes, smoking and family history promotes early vascular (biological) ageing. Early vascular ageing is responsible for the development of coronary events. We assessed the nonlaboratory based vascular age across the spectrum of coronary artery disease and correlated with severity and extent of coronary artery disease. Methods: Case records all patients undergoing angiogram for acute coronary syndromes were reviewed. Demographic details, coronary risk factors, clinical diagnosis of acute coronary syndrome and angiographic details on coronary arteries involvement was noted. Vascular age was then calculated using a nonlaboratory based vascular risk chart. It is derived from a composite score of six pro cardiovascular risk factors which includes age, gender, body mass index, systolic blood pressure (treated and untreated), diabetes and smoking. Results: A total of 242 patient records were analysed. Among them 62/242 (25.61 %) patients were having chronic stable angina, 72/242 (29.75%) unstable angina, and 108/242 (44.62%) myocardial infarction. The mean age of the patients was 56.1±10.7, whereas the vascular age and accelerated vascular age was 71.0±12.0 years and 14.5±8.2 (median 15) years respectively. Conclusion: We did not find a significant difference in vascular age with either severity or extent of coronary vascular disease, even though the risk factors such as age, gender, hypertension, diabetes and smoking significantly varied across the spectrum of coronary artery disease.

 

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DOI: http://dx.doi.org/10.21088/jcms.2454.7123.3217.5

Keywords

Vascular Age; Myocardial Infarction; Unstable Angina; Chronic Stable Angina; Chronological Age; Coronary Arteries. 

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