Abstract

A major cause of maternal and perinatal morbidity and mortality, Preeclampsia (PE) is predominantly thought to be a consequence of impaired placentation. PE can be subdivided into early onset PE and late-onset PE. Early identification of pregnancies at high risk of early onset PE is a major challenge in modern obstetrics and undertaking measures to improve placentation and reduce the prevalence of the disease is the need of the hour. Large number of potential biochemical and biophysical markers have been identified which may help in predicting the risk of developing pre-eclampsia. Numerous clinical tests have been done to establish a reliable method to predict pre-eclampsia.

• 1.   Poon LC, Nicolaides KH. Early prediction of preeclampsia. Obstet Gynecol Int. 2014;2014:297397.
• 2.   Saxena Richa; Bedside Obstetrics and Gynecology for Postgraduates; Edition, 2/e; Publishing Year, 2014.
• 3.   Khong TY, de Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and by small-for-gestational age infants. British Journal of Obstetrics & Gynaecology. 1986;93(10):1049–1059.
• 4.   Martin AM, Bindra R, Curcio P, Cicero S, Nicolaides KH. Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11–14 weeks of gestation. Ultrasound in Obstetrics and Gynecology. 2001;18(6):583–586.
• 5.   Sudha Salhan; Textbook of Gynaecology; Jaypee Brothers; Edition 1/e; Publishing year 2011.
• 6.   Sheth Shirish; Essentials of Obstetrics; Jaypee Brothers; Edition 3/e; Publishing year 2017.
• 7.   Asha Oumachigui, S Soundara Raghavan, S Habeebullah; Essential obstetrics; Universities Press India (Private Limited); Edition 1/e; Publishing year 2011.
• 8.   Renu Mishra; Ian Donald’s Practical Obstetric Problems; Pages 190-191; Wolter Kluver (India) Pvt. limited; Edition 8/e; 2020.
• 9.   Bujold E, Roberge S, Lacasse Y, et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstetrics and Gynecology. 2010;116(2):402–414.
• 10.   Koopmans CM, Bijlenga D, Groen H, et al. Induction of labour versus expectant monitoring for gestational hypertension or mild preeclampsia after 36 weeks’ gestation (HYPITAT): a multicentre, open-label randomised controlled trial. The Lancet. 2009;374(9694):979–988.
• 11.   Tayyar A, Garcia-Tizon Larroca S, Poon LC, Wright D, Nicolaides KH. Competing risks model in screening for preeclampsia by mean arterial pressure and uterine artery pulsatility index at 30–33 weeks’ gestation. Fetal Diagnosis and Therapy. 2014;36(1):18–27.

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