K K Gavi Post Graduate, Department of Orthopedics, MS Ramaiah Medical College, Bengaluru 560054, Karnataka, India
J S R G Saran Post Graduate, Department of Orthopedics, MS Ramaiah Medical College, Bengaluru 560054, Karnataka, India
Durai Anand T Assistant Professor, Department of Orthopedics, MS Ramaiah Medical College, Bengaluru 560054, Karnataka, India
Address for correspondence: K K Gavi, Post Graduate, Department of Orthopedics, MS Ramaiah Medical College, Bengaluru 560054, Karnataka, India E-mail: k.gavikrishna@gmail.com
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J S R G Saran, Gavi K, Durai Anand T. Novel Surgical and Antibiotic Strategy for Treating Septic Arthritis after Total Knee Arthroplasty caused by Serratia Marcescens: A Case Report. Jr. Orth. Edu. 2024;10(2):55–61.
Timeline
Received : May 11, 2024
Accepted : July 26, 2024
Published : August 25, 2024
Abstract
Introduction: Septic arthritis is a dreadful condition affecting joints which warrants an emergency arthrotomy in tandem with debridement followed by intravenous antibiotics during the peri-operative period. It generally affects larger joints, namely the hip, knee, shoulder, ankle and elbow. Serratia marcescens causing septic arthritis is uncommon in
an immunocompetent individual and the available literature on the same, is limited. Case presentation: A 73-year-old female diabetic patient, had presented to the casualty with swelling in the right knee with local rise of temperature and limited movements for five days. She had undergone left total knee arthroplasty four months ago with no postoperative complications and was ambulating well. The radiographs did not show signs of gross abnormality. Synovial fluid aspirated from the affected knee was found to have Serratia marcescens infection localized to the joint, as the blood culture was negative for the same organism. Left knee arthrotomy with debridement was done along with polyethylene liner exchange and local antibiotic delivery via calcium sulphate crystals mixed with vancomycin, tobramycin and gentamicin. Following this, she was given intravenous antibiotics based on the culture and sensitivity report. Conclusion: Septic arthritis of the knee joint caused by Serratia marcescens is a rare occurrence, especially following total knee arthroplasty. Hence special attention had to be given for surgical planning and treatment regimen. Knee effusion with painful limitaion of movements is a pathognomonic sign of a septic knee. Initial antibiotic cover remains the mainstay of the treatment but in an acute setting, knee arthrotomy with debridement and application of local antibiotic delivery gave excellent results.
References
1. Whitehead W. The “Open Method” in septic arthritis of the knee [Internet]. British Medical Journal. U.S. National Library of Medicine; 1902 [cited 2024Oct31]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC2401295/
2. Olut A, Tosun S, Ari A, Şeker B, Erkan H, Altay T. [PDF] posttraumatic septic arthritis due to serratia marcescens: Case report and review of literature: Semantic scholar [Internet]. Mediterranean Journal of Infection Microbes and Antimicrobials. 1970 [cited 2023Apr13]. Available from: https://www.semanticscholar. org/paper/Posttraumatic-Septic-ArthritisDue-to-Serratia-Case-Olut-Tosun/251b8549fa1 b4eb5f23392a1abf8a97ee2fbcfd7
3. Momodu II, Savaliya V. Septic arthritis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.
4. Vasso M, Capasso L, Corona K, Pola E, Toro G, Schiavone Panni A. Periprosthetic knee infection: treatment options. Orthopedic Reviews. 2022;14(4). doi:10.52965/001c.37537
5. Debridement, antibiotics, and implant retention for a rare Serratia marcescens infection after total knee arthroplasty: A case report [Internet]. Jocr.co.in. Journal of Orthopaedic Case Reports; 2024 [cited 2024 Nov 6]. Available from: https:// jocr.co.in/wp/2024/04/10/debridementantibiotics-and-implant-retention-for-a-rareserratia-marcescens-infection-after-total-kneearthroplasty-a-case-report/
6. Zahar A, Sarungi M. Diagnosis and management of the infected total knee replacement: a practical surgical guide. J Exp Orthop. 2021 Feb 22;8(1):14. doi: 10.1186/s40634-021-00333-2. PMID: 33619607; PMCID: PMC7900357.
8. Khanna A, Khanna M, Aggarwal A. Serratia marcescens- a rare opportunistic nosocomial pathogen and measures to limit its spread in hospitalized patients [Internet]. Journal of clinical and diagnostic research: JCDR. U.S. National Library of Medicine; 2013 [cited 2024Oct31]. Available from: https://www.ncbi. nlm.nih.gov/pmcarticles/PMC3592283/
9. Stock I;Burak S;Sherwood KJ;Gruger T;Wiedemann B; Natural antimicrobial susceptibilities of strains of ‘unusual’ serratia species: S. Ficaria, S. Fonticola, S. Odorifera, S. Plymuthica and S. Rubidaea [Internet]. The Journal of antimicrobial chemotherapy. U.S. National Library of Medicine; [cited 2023Apr13]. Available from: https://pubmed. ncbi.nlm.nih.gov/12654765/
10. Stock I, Grueger T, Wiedemann B. Natural antibiotic susceptibility of strains of serratia marcescens and the S. liquefaciens complex: S. liquefaciens sensu stricto, S. Proteamaculans and S. grimesii. International Journal of Antimicrobial Agents. 2003;22(1):35–47.
11. Hadid H, Usman M, Thapa S. Severe osteomyelitis and septic arthritis due to serratia marcescens in an immunocompetent patient [Internet]. Case reports in infectious diseases. U.S. National Library of Medicine; 2015 [cited 2024Oct31]. Available from: https://www.ncbi. nlm.nih.gov/pmcarticles/PMC4486246/
12. Mahmoud SSS, Odak S, Qazzafi Z, McNicholas MJ. Primary total knee arthroplasty infected with serratia marcescens [Internet]. BMJ case reports. U.S. National Library of Medicine; 2012 [cited 2023Apr13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC4542562/
13. Stimulan® rapid cure beads for bone & joint infection [Internet]. International. 2018 [cited 2024 Nov 6]. Available from: https:// biocomposites.com/our-products/stimulan/
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
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Cite this article
J S R G Saran, Gavi K, Durai Anand T. Novel Surgical and Antibiotic Strategy for Treating Septic Arthritis after Total Knee Arthroplasty caused by Serratia Marcescens: A Case Report. Jr. Orth. Edu. 2024;10(2):55–61.
This license enables
reusers to distribute, remix, adapt, and build upon the material in any medium
or format for noncommercial purposes only, and only so long as attribution is
given to the creator.
This license enables
reusers to distribute, remix, adapt, and build upon the material in any medium
or format for noncommercial purposes only, and only so long as attribution is
given to the creator.