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Indian Journal of Pathology: Research and Practice

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Morphological Spectrum of Peripheral T Cell Lymphomas and Utility of Immunohistochemistry in the Diagnosis

Sakthisankari Shanmugasundaram* , Sakthisankari Shanmugasundaram* , Dhanalakshmi Arumugam** , Shifa Ibrahim*** , Lavanya KrishnagiriBalan**** , Pavithra Thandavarayan****

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Indian Journal of Pathology: Research and Practice 5(2):p 161-166, May-Aug 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5216.15

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Abstract

 Context: Peripheral T cell lymphomas (PTCLs) are uncommon subtypes of non Hodgkin lymphoma (NHL). The diagnosis is often challenging and not infrequently misdiagnosed. Aims: To analyse the morphological and immunohistochemical profile of Peripheral T cell lymphoma. Settings and Design: This study was carried out at the Department of Pathology, where cases were recruited using consecutive sampling method. Methods and Material: Immunohistochemical staining was performed in all cases of lymphoma and results were analysed. Statistical Analysis Used: Frequency distribution of the diagnoses was studied. Results: There were six casesof Peripheral T cell lymphoma – unspecified ( CD3+, CD20), two cases of Angioimmunoblastic T cell lymphoma (AITL)(CD3+, CD10+, CD23+), one case of Lennert’s lymphoma(CD3+,CD20) and a hepatosplenic T cell lymphoma(CD3+,CD2+). Conclusions: PTCLs constituted for 20% of NHLs. Immunohistochemistry was helpful in diagnosis when differentiation from Hodgkin lymphoma was difficult morphologically.

Keywords: Angioimmunoblastic T Cell Lymphoma; Lennert’s Lymphoma; Lymphoma; Non Hodgkin Lymphoma; Peripheral T Cell Lymphoma.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5216.15

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