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Low Dose Magnesium Sulphate for Management of Eclampsia, Preeclamisa: An Evidence Based Alternative to Pritchard Regime

Rajiv Dabade, Assistant Professor, Dept. of Obstetrics and Gynaecology, Ashwini Rural Medical College Hospital and Research Centre, Kumbhari, Solapur, Maharashtra 413006, India , Sardesai Suman1 , Rajiv Dabade2 , Kelkar Archana3 , Mulay Bharat4

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Indian Journal of Obstetrics and Gynecology 7(1):p 85-89, Jan-Mar 2019. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.7119.15

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Abstract

Background: To evaluate the efficacy of low dose MgSO4 Regime in management of eclampsia and comparing it with Pritchard Regime regarding control of convulsions, Serum Magnesium levels, Maternal and perinatal outcome. Method: In this study total 120 Cases of eclampsia were included. Sixty Cases were treated by Pritchard regime and 60 cases by low dose Regime. Control of convulsions was studied in both groups. Serum Magnesium levels were done after loading dose and maintenance dose in both groups. Result: In 56 Cases (93.33%) in low dose regime and 57 (95%) in Pritchard regime, convulsions were controlled with loading dose itself. Recurrence rate was 4 (6.66%) in low dose regime and 3 (5%) in Pritchard regime. This difference in recurrence rate is statistically insignificant. The average serum Magnesium levels in low dose regime was 4.23 + 1.51 mg/ dl while in Pritchard regime it was 5.47+1.98 mg/dl. Conclusion: Low dose MgSO4 Regime is as effective as Pritchard regime in controlling and preventing the recurrence of Convulsions in eclampsia. Though there is statistical difference in Serum Magnesium levels in both regimes but there is no statistical difference as far as the Control of Convulsions.

Keywords:Low dose Magnesium Sulphate regime; Pritchard regime; Eclampsia; Convulsion.

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.7119.15

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