Home > Journals > Indian Journal of Obstetrics and Gynecology

Indian Journal of Obstetrics and Gynecology

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Local Ultrasound Guided Intra-Embryonic KCL Instillation with Systemic Methotrexate Versus Methotrexate Alone in Management of Live Tubal Ectopic Pregnancy: A Case Series

Nutan Agarwal* , Nutan Agarwal* , Vidushi Kulshrestha** , Alka Kriplani* , Neerja Bhatla*

Author Information

Licence:



Indian Journal of Obstetrics and Gynecology 5(1):p 13-18, January - March 2017. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.5117.1

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

 Objective: To compare efficacy of systemic methotrexate with concurrent intra-embryonic potassium chloride (KCl) instillation versus systemic methotrexate alone in cases of live unruptured ectopic pregnancies. Method: In this retrospective comparative study conducted in tertiary care centre; six patients with documented cardiac activity suitable for medical management were given ultrasound-guided intra-embryonic KCl along with systemic methotrexate (Mtx) (Group-1). Their response was compared with six historical cases managed with systemic Mtx alone (Group-2). Results: Medical management was successful in 100% patients in Group-1 treated with combined KCl and Mtx, all responded to only single dose of Mtx. In Group-2, success rate was 83% where 2/6(33.3%) cases were successfully treated with single dose; 3/6(50%) patients responded to 2nd dose of Mtx and 1/6(16.7%) case had rupture. Mean duration for hCG to become negative was 5 weeks (range 3-7 weeks) in Group-1 versus 7.2 weeks (range 4-10 weeks) in Group-2. Conclusion: Live unruptured tubal ectopic pregnancies can be effectively managed with intraembryonic KCl and concurrent systemic Mtx therapy. Addition of KCl alleviates the need for second Mtx dose, minimizes the risk of rupture and results in faster fall of hCG. Patients with high baseline hCG can also be effectively treated with this combined treatment.

Keywords: Live Ectopic Pregnancy; Medical Management; Methotrexate; KCl Injection. Synopsis: Ultrasound-guided intraembryonic KCl instillation with systemic methotrexate may alleviate need for second Mtx dose, minimize risk of rupture and reduce follow-up with serial âhCG.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.5117.1

Keywords


Article Level Metrics

Last Updated

Thursday 18 June 2026, 02:31:37 (IST)

1422

Accesses

6
152
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share