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Indian Journal of Pathology: Research and Practice

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Intraoperative Squash Cytology of Central Nervous System Lesions: Review of an Eight-Year Experience

Padmaja K, Associate Professor, Department of Pathology, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana 500068, India. , Nalinimohan C.1 , Padmaja K.2 , Shailaja P.3 , Deshpande A.K.4

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Indian Journal of Pathology: Research and Practice 7(10):p 1095-1098, October 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.71018.9

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Abstract

 Background: Intraoperative squash cytology is a simple and reliable technique for rapid intraoperative diagnosis of neurosurgical specimens. Intraoperative squash cytology is a fairly accurate diagnostic modality which can be used in place of frozen sections. Aim: To assess the diagnostic accuracy of the squash preparation and to compare it with the histopathology sections. Materials and Methods: This study was conducted over a period of eight 8 years (May 2010 to June 2018) which included 131 patients with CNS lesions. The cytological preparations were stained by the rapid H & E method. The squash interpretation was compared with the paraffin section diagnosis. Results: Of the 131 patients, Squash cytology diagnosis was offered in all the cases. With hematoxylin and eosin-stained histopathology sections as the gold standard, the diagnostic accuracy of squash cytology was 95.4% (125/131). Among these cases, gliomas formed the largest group comprising of 50 cases (38.1%). The accuracy of squash cytology in this group was 94% (47/50). Conclusions: CNS squash preparations can be used for rapid and reliable intraoperative diagnosis for CNS lesions. 

Keywords: Central Nervous System Lesions; Intraoperative  Diagnosis; Squash Preparation.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.71018.9

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