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Incidence of Expression of ER, PR and Her 2 Neu in Infiltrating Ductal Carcinoma Breast: A Cohort Study

Bhupinder Kaur Batth , Neha Sharma1 , Bhupinder Kaur Batth2 , Mridu Manjari3 , Arshdeep Kaur4 , Ranjan Agrawal5

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Indian Journal of Pathology: Research and Practice 8(6):p 745-753, November-December 2019. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.8619.5

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Neha Sharma, Bhupinder Kaur Batth, Mridu Manjari et al. Incidence of Expression of ER, PR and Her 2 Neu in Infiltrating Ductal Carcinoma Breast: A Cohort Study. Indian J Pathol Res Pract. 2019;8(6):745–753.

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Abstract

Background: Breast cancer is one of the leading cancer affecting women in India. An early diagnosis has a great significance especially since it carries a high morbidity and mortality rate. It is common among women in both developed and developing countries. Objectives: The present study was carried out to determine the histopathological and immunohistochemical pattern of invasive ductal carcinoma breast in a tertiary care institute. Methodology: 1418 cases of breast cancer diagnosed as invasive ductal carcinoma (IDC) were studied in the department of pathology of a teaching hospital. Estrogen receptor (ER), Progesterone receptor(PR) and Her-2/Neu expression were assessed using immunohistochemical staining and correlated with other prognostic factors including age, tumour size, grade and histomorphological type. Study Area: The study was carried out in the department of histopathology of a tertiary care institute in northern India. Study Design: Formalin fixed paraffin embedded paraffin blocks were analysed. The study duration was 9 years (January 2011 – December 2018). Statistical Analysis: The results were analyzed using SPSS statistical package version 26.

Keywords: Carcinoma; Breast; Mastectomy; IHC; ER; PR; Her-2/Neu; Prognosis.

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Neha Sharma, Bhupinder Kaur Batth, Mridu Manjari et al. Incidence of Expression of ER, PR and Her 2 Neu in Infiltrating Ductal Carcinoma Breast: A Cohort Study. Indian J Pathol Res Pract. 2019;8(6):745–753.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.8619.5

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