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In-Vitro Effect of Picroliv on Plasmodium Berghei Induced Alterations in the Activity of Adenosine Triphosphatase, Aryl Hyrocarbon Hydroxylase Enzymes and MDA in Liver Explant Culture

Aparna Misra* , Aparna Misra* , Manisha Singh* , Anchal Trivedi* , Brijesh Singh Rathore* , Anil K. Balapure**

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Indian Journal of Pathology: Research and Practice 5(2):p 81-86, May-Aug 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5216.1

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Abstract

 Activity of adenosine triphosphatasc (ATPase), aryl hydrocarbon hydroxylase (AHH) enzymes and MDA were investigated employing serumfree murine live explant culture from day 0 through 4 following Plasmodium berghei infection (5% parsitaemia). Results demonstrate the maintenance of ATPase activity in the tissue from normal mice, with attenuation noticed in the tissue from infected animalsthroughout the period of culture The enzyme activity also exhibited responsiveness to Picroliv(0.5mg/ml) added to the culture system, The drug metabolizing enzyme (DME) AHH was also expressed in significantly (p > 0.01) high amounts in both the type of tissue onday 0 decreasing by 10 fold in 24 ours. MDA level also changes during culture and found a very positive response with picroliv. Subsequently, upto day 4, the activity profile did not show much change. However, Picroliv(0.5mg/ml) responsiveness was found to be better in the tissue culture system in the absence of serum with each explants containing the component cell types of liver makes it a novel approach to evaluate the biochemical basis of enzyme regulation.

Keywords: ATPase; AHH; MDA; DME.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5216.1

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