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Indian Journal of Pathology: Research and Practice

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Immunohistochemical Study Characterizing Estrogen and Progesterone Receptors Status in Meningiomas and Correlation with MIB-1 Labeling

Vibha Dutta , Vibha Dutta , Ajay Malik , Tashi , Prabal Deb`

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Indian Journal of Pathology: Research and Practice 1(2):p 61-66, May-Aug 2012. | DOI:

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Abstract

Background: Meningiomas constitute 13-26% of primary intracranial tumors and have predilection for females. Etiology is multifactorial including environmental causes. WHO classifies meningiomas into three grades based on various morphological criteria. Method: This study was carried out to correlate ER, PR expression, MIB-1 LI and traditional morphological prognostic markers of meningiomas. Sixty seven consecutive cases of meningioma, operated at a tertiary care neurosurgical centre, were analyzed for grade using routine Hematoxylin-Eosin stain; estrogen and progesterone receptor (ER, PR) status by immunohistochemistry; and proliferation index using MIB-1 labeling.Results: Majority were grade I neoplasms, with 11 being atypical and 05 anaplastic variants. The mean MIB-1 LI was 3.05%, 6.38% and 11.9% in grades I, II and III meningiomas respectively. ER expression was revealed in 20.89% cases with focal positivity, without any significance on correlation with grade, histology and gender. PR reactivity was found in 73% of the tumors. Higher positivity is found with low grade meningiomas, while high grade meningiomas are associated with negative PR expression. Unpaired t-test showed significant difference found in mean MIB-1 LI in PR positive and negative groups.Conclusion: PR and MIB-1 LI immunohistochemical staining emerged as useful supplements of routine histopathological assessment and can be used to provide additional information regarding behavior and response to treatment.

Keywords: Hormone receptor; Immunohistochemistry; Meningioma; Proliferation rate. 

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