Home > Journals > Indian Journal of Pathology: Research and Practice

Indian Journal of Pathology: Research and Practice

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Immunohistochemical Correlation with Morphological Evolution of Urinary Bladder Tumors

Vijay Neha Sr. Demonstrator, Jawaharlal Nehru Medical College, Ajmer, Rajasthan 305001, India. , Dargar Parul1 , Vijay Neha2 , Khan Shahar Bano3 , Suryavanshi Moushumi4

Author Information

Licence:



Indian Journal of Pathology: Research and Practice 7(4):p 429-438, April 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7418.4

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

 

Context: Urinary bladder diagnosis can be challenging and conventional markers used were cytokeratins. The new additions are GATA 3, uroplakin and S100P. This study helps to analyze immunohistochemical expression of panel of markers across the spectrum of urinary bladder tumors.

Aims: 1. to evaluate immunohistochemical expression in various subtypes of urothelial neoplasms of the urinary bladder and to correlate this expression with the grade of the tumor. 2. To distinguish between reactive urothelium and carcinoma in situ/ dysplasia using immunoprofile work up.

Settings and Design: Study was performed in the department of Pathology in RGCIRC, Delhi with 70 cases of urinary bladder lesions during period of one year.
Methods and Material: longitudinal study
Statistical Analysis: The tissue sections were scored using CK, UROPLAKIN II, GATA 3, S100P, CD44, p16 and KI 67

Results: 1. CK7+ and CK20+in 92% and 77% cases. p16+ in 83% and CD 44+ in 84%. Newer markers: Uroplakin II-75%; S100P-82% and GATA3-96%positivity. CD44+ in reactive urothelium 5/5 and CK20+ in CIS (12/12) cases. p16+ in 4/5 cases of reactive atypia and CIS 12/12 cases.

Conclusions: The markers are sensitive for urothelial origin & have to be used as panel wherever required.

Keywords: Uroplakin II; Gata 3; Bladder Carcinoma

 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7418.4

Keywords


Article Level Metrics

Last Updated

Sunday 12 July 2026, 13:45:08 (IST)

2018

Accesses

3
434
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share