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Histopathological Effects of Melatonin in Hyperammonemia Induced Wistar Rats

P. Jasmin Lena1* , P. Jasmin Lena1* , P. Subramanian2

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RFP Journal of Biochemistry and Biophysics 1(2):p 81-87, July - December 2016. | DOI: N/A

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Abstract

 Exposure to ammonium acetate induces acute and chronic renal injuries as well as oxidative stress in rats. The aim of this study was to evaluate the effect of exogenous melatonin (MLT) treatment on ammonium acetate induced oxidative stress and hepatotoxicity in Wistarrats using biochemical parameters and histopathology. For histopathological evaluation, liver of all rats were excised and processed for light microscopy. Liver sections of ammonium acetate treated group showed changes in microanatomy. In contrast, these deleterious histopathological alterations resulting from ammonium acetate induced hepatotoxin were absent after MLT treatment in ammonium acetate treatment+MLT treated group of rats. In conclusion, our results demonstrated that MLT through its antioxidant activity effectively ameliorated ammonium acetate induced hepatotoxicity.

Keywords: Melatonin; Ammonium Acetate; Hepatotoxicity; Histopathology; Antioxidants

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