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Histomorphological Study of Skin Lesions in Punch Biopsy Specimens with Special References to Neoplastic Lesions

S Susmitha, Postgraduate, Department of Pathology, BLDEU’s (deemed to be university), Shri B M Patil Medical College Hospital and Research Centre, Vijayapura, Karnataka 586103, India. , Mamatha K.1 , S. Susmitha2 , Sathyashree K.V.3 , Rama Devi P.4 , Raga Sruthi D.5 , Lynda Rodrigues6

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Indian Journal of Pathology: Research and Practice 7(7):p 841-846, July 2018. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7718.5

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Abstract

Introduction: Dermatological lesions are common in all nations but the incidence and spectrum varies from place to place. They can be broadly categorised into non-neoplastic lesions and neoplastic lesions. Clinically they usually presents with overlapping features like hyperpigmentation, hypopigmentation, macules, papules, nodules or either patch. Skin biopsy is the most common ancillary technique used for confirmation of the clinical diagnosis. The present study was conducted to describe the histopathological spectrum of lesions in skin biopsies.

Materials and methods: This is a 2 years retrospective study conducted in department of Pathology, BLDEU’s (deemed to be university) Shri B M Patil Medical College Hospital and Research Centre, Vijayapura, Karnataka and includes 258 cases. All the skin biopsies received were reviewed from archives of the department and examined under light microscopy.

Results: Among 258 cases, 120 cases were males and 138 cases were females with male:female ratio being 0.8:1. Further these lesions were classified into non-neoplastic and neoplastic lesions. Of the 258 cases, 235 cases were nonneoplastic lesions and 23 cases of neoplastic origin. Among the non-neoplastic lesions infectious dermatoses (41.28%) formed the predominant part with leprosy (91 cases) constituting 38.7%. This was followed by inflammatory (40%), vesiculobullous (11.06%), granulomatous (2.12%), lesions of melanocytes (3.82%) and miscellaneous lesions (1.70%). Out of 23 neoplastic lesions, benign were 15 and malignant were 8 cases.

Conclusion: Dermatological lesions are the cutaneous manifestations of exposure to both intrinsic and extrinsic environmental agents. Various lesions have been reported ranging from non-specific inflammatory dermatoses to infective dermatoses and neoplastic lesions.

Keywords: Skin Lesions; Non-Neoplastic Lesions; Infectious Dermatoses; Neoplastic Lesions.

 

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7718.5

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