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Histomorphological Evaluation of Lymph Node Lesions: A Two Year Study

Surekha H. Bhalekar , Hemant B. Bhalekar* , Surekha H. Bhalekar**

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Indian Journal of Pathology: Research and Practice 6(2 (Part-2)):p 439-444, APRIL - JUNE 2017. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.62(pt-II)17.18

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Abstract

Introduction: Lymph node pathology is complex as it can be affected by a variety of non-neoplastic and neoplastic diseases. Histopathological examination especially at low magnification gives considerable information and helps to arrive at a diagnosis. Aims and Objectives: To study diagnostic histopathological patterns of various lymph node lesions and to study in depth rare lymph node lesions. Materials and Methods: This was a retrospective study carried out in the department of Pathology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, over a period of two years. A total of 255 lymph nodes were examined on routine histopathology and immunohistochemistry was done in a few cases of lymphomas. Observations and Results: There were 153 males and 102 females in the study and the age ranged from 1 year to 85 years. The non neoplastic causes were common for lymphadenopathy and in specific causes, tuberculosis was most common Incidence of metastatic malignancy was 9 % and of lymphomas was 11 %. Conclusion: Lymphadenopathy occurs more commonly due to non-neoplastic causes. Metastatic involvement of lymph nodes is mostly due to carcinomas. Histological evaluation of lymph nodes at low magnification helps to evaluate the architectural patterns of lymph nodes. These along with the identification of the cellular composition help in the diagnosis of lymph node diseases.

Keywords: Lymph Node Lesions; Lymphadenopathy; Immunohistochemistry.

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.62(pt-II)17.18

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