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Haemodynamic Response Associated With Laparoscopic Cholecystectomy: Outcome of Oral Clonidine as a Premedicant and Post Operative Analgesic- A Clinical Study

Prajwal Patel H.S., Assistant Professor, Department of Anaesthesiology, Anaesthesia, Adhichunchanagiri Institute of Medical Sciences AIMS, BG Nagara- 571448, Nagamangala (tq), Mandya, Karnataka. , Prajwal Patel H.S.* , Shashank M.R.* , Shivaramu B.T.***

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Indian Journal of Anesthesia and Analgesia 4(2):p 469-475, April - June 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.18

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Abstract

Background:  Laparoscopy provides various advantages than conventional cholecystectomy but may lead to alteration in cardiovascular and pulmonary physiology and stress response. Objective: The aim of this study is to assess the outcome of oral clonidine as a premedicant for haemodynamic stability in laparoscopic cholecy stectomy and as a postoperative analgesic. Materials and Methods: One hundred and fifty adult patients categorized as ASA physical status I or II, time lined for laparoscopic cholecystectomy were chosen and randomly allotted to two groups P & C. Group C (clonidine) received Tab. clonidine 150  g orally and Group P (placebo) received Tab.ranitidine 150mg orally as premedication 90 minutes before scheduled laparoscopic cholecystectomy. Haemodynamic response in the intraoperative period and postoperative analgesic requirements were recorded.Results: Significant haemodynamic variation was noted in the group P as compared to group C. Mean heart rate varied from 74.42 ± 9.13 to 91.84 ± 9.11 (Mean±SD ) in group C and 84.64 ± 9.25 to 110 ± 13. 95 in group P. Systolic, Diastolic and Mean blood pressures also showed similar  variations. Intensity of pain, nausea and vomiting was also less in the group C in the early postoperative period. Conclusion: It can be concluded from these results that,premedication with oral clonidine 150 µg provides stable haemodynamics and prevents against stress response due to pneumoperitoneum in laparoscopic cholecystectomy patients and reduces postoperative analgesic requirements.
 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.18

Keywords

Haemodynamic Response; Laparoscopy; Cholecystectomy; Pneumoperitoneum; Oral Premedication; Clonidine; Post-Operative Pain

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