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Evaluation of Coagulation Disturbances in Patients with Polycystic Ovary Syndrome

Radha Sangavi, Associate Professor, Dept. of Obstetrics & Gynecology, Raichur Institute of Medical Sciences, Raichur, Karnataka – 584102, India. , Radha Sangavi1 , Amrutha Bennal2

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Indian Journal of Obstetrics and Gynecology 6(3):p 287-290, May-June 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6318.15

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Abstract

Background: Polycystic ovarian syndrome (PCOS) patients are prone to develop insulin resistance with compensatory hyperinsulinemia, dyslipidemia, hypertension, and obesity. There is evidence that plasma levels of several hemostatic factors are modulated by hyperglycemia, insulin resistance with compensatory hyperinsulinemia, proinflammatory agents, and dyslipidemia, all of which are typical in PCOS. Hence; we planned study to evaluate the coagulation disturbances in PCOS patients. 

Materials & Methods: The present prospective study included assessment of 50 women with PCOS and 50 controls. Parameters like platelet count, bleeding & clotting time, prothrombin time, APTT, fibrinogen levels are tested. All the results will be analyzed by SPSS software 16.0. 

Results: A total of 100 subjects were included in the present study; 50 with PCOS, and 50 healthy controls. Fibrogen activity was found to be significantly higher in subjects of PCOS group. 

Conclusion: Prothrombotic state might occur with greater frequency in PCOS women.

Keywords: Coagulation; Disturbances; Polycystic Ovary Syndrome.

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6318.15

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