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Efficacy of Stair Step Protocol of Clomiphene Citrate in PCOS

Aakarsh Sinha* , Aakarsh Sinha* , Seema Sharma**

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Indian Journal of Obstetrics and Gynecology 5(1):p 43-47, January - March 2017. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.5117.7

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Abstract

 Objective: To evaluate the effectiveness of extended clomiphene citrate therapy in the women who failed to ovulate despite of traditional regimen of clomiphene citrate. Study Design : It is a prospective study done on 25 women who failed to ovulate despite of standard dose of clomiphene citrate. The stair step protocol is performed as follows – 50mg of clomiphene citrate is given for 5 days. USG done on day 11 to day 14 . If result is unresponsive, immediate begins 100mg of clomiphene citrate for 5 days . Repeat USG in 1 week. If result is unresponsive start 150mg of clomiphene citrate for 5 days and repeat USG after 1 week. Result : Total time required to ovulate in extended clomiphene citrate is less as compared to traditional regimen in women with ovulatory disorders.

Keywords: Extended Clomiphene Citrate; Stair Step Protocol; Ovulation.

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.5117.7

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