Abstract

Introduction: The zinc ion plays an essential role with insulin in the pancreatic β cell, activating multiple cell signaling cascades. It also plays a relevant role in antioxidant defense in patients with type 2 diabetes mellitus. Supplementation of zinc has been found to improve insulin level and fasting glucose level. Sesame (Sesamum indicum, family Pedaliaceae) seeds are one of the richest sources of zinc, iron and also have pharmacological activities such as antidiabetic, antihypertensive, antibacterial and antioxidant effects. Objectives: the aim of present study, to evaluate serum zinc level in normal and type-2 diabetic patients and to assess the effect of zinc food supplementation in the improvement in control of blood glucose level. Methodology: In the study normal (n-30) and type-2 diabetic (n-30) volunteer subjects of both genders (age 35-50 years) enrolled for the study. All normal and diabetic subjects were screened for FBG and serum zinc level, to find out if there is any correlation between serum zinc level and FBG level. Then the group of diabetic subjects was supplemented biscuits prepared by incorporation of defatted sesame seeds powder with 3mg/day zinc content. Intervention was done for 45 days. All diabetic subjects were screened after zinc supplementation for FBG and serum Zn level, to compare both normal and diabetic subjects to assess the effect of zinc in diabetic subjects FBG level again. Results: The results revealed that the mean of serum zinc level in normal subjects was 107.34±24.04 μg/dl and diabetic subjects it was 61.37±13.86 μg/dl. The mean of FBG in non-diabetic subjects was 95.86±8.13 mg/dl and in diabetic subjects was 131.06±11.64mg/dl. After the supplementation of zinc in diabetic subjects in serum zinc level was increased to 109.53±14.79 µg/dl and FBG decreased to 115.26±13.51 mg/dl and these changed were significantly at 1% level of significance. Conclusion: Zinc supplementation in patients with diabetes improves glycemic control and promotes healthy life. So, in study the role of zinc has been found to be associated with the improvement of glycemic control.

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