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Effect of Dexmedetomidine on Haemodynamic Response to Pneumoperitoneum in Patients Undergoing Laparoscopic Cholecystectomy

Harish kumar P, Assistant Professor, Department of Anaesthesia, JSS Hospital, Mysuru, Karnataka 570004, India. , Shobharani S1 , Harish Kumar P2 , Rehana Sikora3 , Jalaja Koppa Ramegowda4 , Anita Pramod Nair5 , Sham Prasad MS6

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Indian Journal of Anesthesia and Analgesia 6(1):p 67-76, Jan-Feb 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6119.9

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Shobharani S, Harish kumar P, Rehana Sikora et al. Effect of Dexmedetomidine on Haemodynamic Response to Pneumoperitoneum in Patients Undergoing Laparoscopic Cholecystectomy. Indian J Anesth Analg. 2019;6(1):67-76.

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Abstract

Background: As laparoscopic cholecystectomy is a routinely performed surgery, it is desirable to have a stable intraoperative haemodynamic status. This study is designed to evaluate the efficacy of single intravenous bolus dose of dexmedetomidine, given 10 minutes before induction of anesthesia to provide hemodynamic stability in patients undergoing laparoscopic cholecystectomy. Materials & Methods: A Double blind randomized controlled study was conducted in the department of Anaesthesiology, Manipal Hospital Bangalore, Patients undergoing elective laparoscopic cholecystectomy, under general anaesthesia for a period of one year from June 2013 to May 2014. Total 60 patients belonging to ASA physical status I and II, in the age group of 18 to 65 years scheduled for elective laparoscopic cholecystectomy surgery were selected for this study. The two groups, Dexmedetomidine and control, were comparable with respect to age, sex, weight and ASA physical status. Results: We observed lesser magnitude of variation in HR, SBP, DBP, MAP atinsufflation of pneumoperitoneum until 30 minutes post pneumoperitoneum in dexmedetomidine group compared to control group (p<0.05). During pneumoperitoneum the maximum SBP and MAP attained in dexmedetomidine group was lesser compared to control group (p<0.001). Dexmedetomidine group also had less number of episodes of increase in SBP and MAP of more than 20% of baseline. We also found that the requirement for more than 1% of isoflurane in control group was higher (73%) compared to dexmedetomidine group. The recovery time was found to be similar in both groups. Conclusion: In conclusion, dexmedetomidine at a dose of 1 μgkg-1 bolus given at induction of anesthesia over 10 minutes resulted in statistically significant hemodynamic stability during pneumoperitoneum in patients undergoing elective laparoscopic cholecystectomy surgeries. 

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Shobharani S, Harish kumar P, Rehana Sikora et al. Effect of Dexmedetomidine on Haemodynamic Response to Pneumoperitoneum in Patients Undergoing Laparoscopic Cholecystectomy. Indian J Anesth Analg. 2019;6(1):67-76.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6119.9

Keywords

Dexmedetomidine; Haemodynamic response; Laparoscopic Cholecystectomy; Pneumoperitoneum. 

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