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Case Report

Disseminated Angioinvasive Aspergillosis

Susmitha M.S.* , Susmitha M.S.* , Babu K. Ramesh**

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Indian Journal of Pathology: Research and Practice 5(3):p 417-419, Sept - Dec 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5316.32

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Abstract

 Disseminated angioinvasive aspergillosis is a rare fatal disease seen in immunocompromised hosts. Invasive pulmonary aspergillosis have been reported in immunocompetant patients with preexisting COPD having bulla, tuberculous cavity or bronchial cyst. A 22 years aged male patient was hospitalized after consumption of ratol, a rodenticide poison. Investigations revealed altered liver function,leukocytosis of 16,600cells/mm3, HIV and HbsAg negative status. Clinical diagnosis was fulminant hepatocellular failure.On fifth day, he suddenly developed massive haematemesis and dyspnea and succumbed to death. Autopsy revealed disseminated angio-invasive aspergillosis involving the lungs, heart and kidney. On histopathology, Invasive pulmonary aspergillosis, myocarditis, endocarditis, angioinvasion and renal aspergillosis showing septate hyphae branching at acute angle were seen. We report this case of invasive aspergillosis occurring in a non immunocompromised person, diagnosed on autopsy.Our case upholds the significance of autopsy.

Keywords: Aspergillosis; Autopsy; Disseminated; Hyphae.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5316.32

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