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Diagnostic Evaluation of Patterns of Bone Marrow Involvement in Myelophthisic Anemias

V. Shanthi, Flat no. 103, Anjani SVGK Towers, Sri Hari nagar, Ramalingapuram, Nellore, Andhra Pradesh, India. , V. Shanthi* , B.V. Vydehi* , P.Pavani** , M. Sushmalatha*** , V. Tejaswini*** , Tanusha Ethamakula***

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Indian Journal of Pathology: Research and Practice 6(3(part-1)):p 632-635, Jul-Sep 2017. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6317.21

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Background: Bone marrow examination is an important diagnostic tool in the evaluation of cases of myelophthisic anemia. Myelophthisis means replacement of bone marrow elements by the tumor tissue, granulomatous inflammations or fibrosis, which further leads to anemia. Methods: our study was retrospective study which reviewed bone marrow examination of 60 cases with myelophthisic anemia in Narayana Medical College and hospital, during a period of 5years (Jan 2011Jan 2016). Result: Our study of 60 cases revealed, 53 cases having neoplastic involvement of bone marrow and 7 cases having nonneoplastic pathology. 53 cases having neoplastic involvement showed 49 cases with haematological and 4 cases with secondary metastatic deposits. In our study 50% cases presented with anemia, 30% with leukoerythroblastic picture, 13.33% cases presented with pancytopenia & 6.66% cases with thrombocytopenia Conclusion: Our study reflected that the common causes of myelophthisic anemia was neoplastic (88.33%) and tuberculosis (42.86%) commonest among the nonneoplastic involvement.

Keywords: Myelophthisic Anemia; Bone Marrow. 

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6317.21

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