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Correlative Study of Ki67 with Other Molecular Markers in Breast Cancer in South Karnataka Population of India

Nanjundaswamy Doddaiah, , Nanjundaswamy Doddaiah

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Indian Journal of Pathology: Research and Practice 8(1):p 106-109, Jun-Feb 2019. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.8119.16

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 40 females aged between 25 to 65 years old having breast cancer were studied during 2016 and August 2018. 15 (37.5%) were tobacco chewers, 4 (10%) were smokers 3 (7.5%) were alcoholic and 18 (45%) were mal-nutritious. Expression of ki67 and its histopathological correlation was found to be 4(10%) patients had IDC grade I malignancy, 22 (55%) had IDC grade II malignancy, 14 (35%) had IDC grade – III malignancy, 5 (12.5%) axillary lymph nodes had negative expression, while 35 (87.5%) expressed positivity for ki67 bio marker. The size of tumour were 4 (10%) were <2 cm and 36 (90%) with > 2 cm in the correlative study of ki67 with PR score value was 0.58, with ER score value was 0.18 and with HER-2/ neu value was 1.0 and all three correlation were statistically insignificant. This study confirmed that increasein ki67 – positivity has poorer prognosis hence ki67 biomarker plays significant role inthe prognostic value in breast cancer

Keywords: Er = Estrogen Receptor; Pr = Progesterone Receptor; Her-2 = Human Epidermal Growth Factor Receptor -2.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.8119.16

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