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Contribution of Robert L. Brent in Field of Pediatrics

Tayade Pratham Bharat, Kasumbiwal Ajay H., Lakhe Siddheshwar A., Kaithi Pavani R.

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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

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Pediatric Education and Research 13(2 (Special Supplement -II)):p 463-465, July-Dec 2025. | DOI: https://doi.org/10.21088/per.2321.1644.13225.114

How Cite This Article:

Kasumbiwal Ajay H., Lakhe Siddheshwar A., Kaithi Pavani R., et al. Contribution of Robert L. Brent in Field of Pediatrics. Pediatr. Edu. Res. 2025; 13(2): 463-465.

Timeline

Received : December 11, 2025         Accepted : December 25, 2025          Published : December 30, 2025

Abstract

Robert L. Brent, a distinguished pediatrician, reproductive biologist, and teratologist, made pioneering contributions to understanding environmental influences on fetal and childhood development. His research significantly advanced knowledge on how radiation, drugs, chemicals, and maternal health factors affect embryonic and pediatric outcomes. Brent’s work was instrumental in establishing evidence-based guidelines on prenatal radiation exposure, helping clinicians accurately assess fetal risk and avoid unnecessary pregnancy terminations. Through extensive experimental studies and clinical consultations, he clarified mechanisms of teratogenesis and emphasized the importance of dose, timing, and biological variability in determining developmental effects. Brent played a key role in shaping pediatric environmental health policies and served as an authoritative voice for physicians, parents, and regulatory agencies. His legacy is reflected in safer clinical practices, improved counseling for pregnant patients, and a deeper scientific understanding of how environmental agents influence pediatric well-being. Key Message: Robert L. Brent’s work transformed pediatric environmental health by establishing evidence-based understanding of how radiation, chemicals, and environmental agents affect fetal and child development. His research provided crucial clinical guidance, prevented unwarranted pregnancy terminations, and shaped modern teratology and pediatric risk assessment.

References

  • 1.   Brent R.L. The effects of embryonic and fetal exposure to X-ray, microwaves, and ultrasound. Pediatr Ann. 1980; 9(6): 219-36.
  • 2.   Brent R.L. Saving lives and changing family histories: appropriate counseling of pregnant women and men and women of reproductive age, concerning the risk of diagnostic radiation exposures during and before pregnancy. Am J Obstet Gynecol. 2009; 200(1): 4-24.
  • 3.   Brent R.L. Utilization of developmental basic science principles in the evaluation of reproductive risks from pre- and postconception environmental radiation exposures. Teratology. 1999; 59(4): 182-204.
  • 4.   Brent R.L. Environmental causes of human congenital malformations: the pediatrician’s role in dealing with these complex clinical problems caused by a multiplicity of
  • 5.   Brent R.L. Radiation teratogenesis. Teratology. 1980; 21(3): 281-98.
  • 6.   Brent R.L. The importance of scholarship and the influence of politics and controversy on radiation and chemical teratology. Reprod Toxicol. 2006; 22(2): 225-30.
  • 7.   Brent R.L., Beckman D.A. Environmental agents and congenital malformations: traditional toxicology meets modern developmental biology. Curr Opin Pediatr. 1990; 2(2): 233-8.
  • 8.   Brent R.L. Counseling patients about exposure to ionizing radiation during pregnancy. JAMA. 1989; 262(19): 2729-31.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.

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Cite this article

Kasumbiwal Ajay H., Lakhe Siddheshwar A., Kaithi Pavani R., et al. Contribution of Robert L. Brent in Field of Pediatrics. Pediatr. Edu. Res. 2025; 13(2): 463-465.

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Received Accepted Published
December 11, 2025 December 25, 2025 December 30, 2025
DOI: https://doi.org/10.21088/per.2321.1644.13225.114

Keywords

Fetal developmentTeratogenesisTeratologyPrenatal radiation exposure

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Timeline

Received December 11, 2025
Accepted December 25, 2025
Published December 30, 2025

licence

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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