Abstract

Background: Infantile hepatic hemangioendothelioma/hemangioma (IHH) is the most common type of benign tumor of Liver, contributing to 12% of all childhood liver tumors. (1) It is a neonate’s common hepatic mesenchymal tumor, 90% being less than six months old. (1) The tumor is slightly more predominant in females. It may be asymptomatic or can cause serious complications like cardiac failure or coagulopathy. There is no treatment protocol established yet and increasing number of cases have been reported. There is a varied treatment options like pharmacological or interventional on the basis of the presentation. IHH is classified as a benign vascular tumor with spontaneous regression in some patients. Case presentation: Here is a 6 month old infant presented with Infantile colic and incidentally diagnosed to have IHH. Imaging like Ultrasonography and MRI confirmed the diagnosis. The child had an asymptomatic presentation and regressed with follow up. Conclusion: Increasing awareness about the condition needed for proper follow up. Early identification and prompt treatment is necessary to avoid fatal complications.

• 1.   Dasgupta M.K., Das S., Patra C., Sarkar S. Symptomatic infantile hepatic haemangioendothelioma successfully treated with steroid. J. Clin Neonatal. 2013 Oct; 2(4):187-9. Doi: 10.4103/2249-4847.123099. PMID: 24404532; PMCID: PMC3883215.
• 2.   Zenge J.P., Fenton L., Lovell M.A., Grover T.R. Case report: infantile haemangioendothelioma. Curr Opin Pediatr. 2002 Feb; 14(1):99-102. doi: 10.1097/00008480-200202000-00018. PMID: 11880743.
• 3.   Mortele K.J., Vanzieleghem B, Mortele B, Benoit Y., Ros P.R. (2002) Solitary hepatic infantile haemangioendothelioma: dynamic gadoliniumenhanced MR imaging findings. Eur Radiol. 2002; 12:862–865.
• 4.   Kunstadter R.H. (1933) Hemangioendothelioma of the liver in infancy. Am J Dis Child, 1933, 46:803-10.
• 5.   Fok T.F., Chan M.S., Metreweli C, Ng P.C., Yeung C.K., Li A.K. Hepatic haemangioendothelioma presenting with early heart failure in a newborn: Treatment with hepatic artery embolization and interferon. Acta Paediatr. 1996; 85:1373–5
• 6.   Mueller B.U., Lopez- Terrade D., Finegold MJ: Tumors of the liver. Principles and practices of Pediatric oncology. Pizzo P.A., Poplack DG(ed): Lippincott Williams and Wilkins, Philadelphia PA; 2006. 887-904
• 7.   Buonomo C., Taylor G.A., Share J.C., Kirks D.R. Abnormalities of the hepatobiliary system. In: Kirks D.R., Griscom N.T., editors. Practical Pediatric Imaging: Diagnostic Radiology of Infants and Children. 3rd ed. Philadelphia: Lippincott-Raven; 1998. pp. 954–79. [Google Scholar]
• 8.   Zhang Z., Chen H.J., Yang W.J., Bu H., Wei B., Long X.Y., Fu J., Zhang R, Ni Y.B., Zhang H.Y. (2010) Infantile hepatic haemangioendothelioma: a clinicopathologic study in a Chinese population. World J. Gastroenterol . 2010, 16:4549–4557
• 9.   Kim T.J., Lee Y.S., Song Y.S., Park C.K., Shim S.I., Kang C.S., Lee K.Y. Infantile haemangioendothelioma with elevated serum alpha fetoprotein: report of 2 cases with immunohistochemical analysis. Hum Pathol. 2010 May; 41(5):763-7. Doi: 10.1016/j. humpath.2009.05.019. Epub 2010 Feb 12. PMID: 20153513.

Data Sharing Statement

Funding