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Comparison of Ramosetron and Dexamethasone for Prophylaxis of Postoperative Nausea and Vomiting in Patients Undergoing Middle Ear Surgeries

Aneesh Rajan , Kishore Keerthy N. , Aneesh Rajan

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Indian Journal of Anesthesia and Analgesia 7(2):p 500-505, Mar-Apr 2020. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7220.9

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Kishore Keerthy N, Aneesh Rajan. Comparison of Ramosetron and Dexamethasone for Prophylaxis of Postoperative Nausea and
Vomiting in Patients Undergoing Middle Ear Surgeries. Indian J Anesth Analg. 2020;7(2):500–505.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

 

Background: Nausea and vomiting are common complications of anesthesia and surgery. Patients undergoing middle ear surgeries are exposed to a higher-risk of Postoperative Nausea Vomiting (PONV).
These complications may alter the results of reconstruction and anatomical alignments. Numerous antiemetics have been studied to prevent and treat PONV in patients undergoing middle ear surgeries. The aim of this study is to compare the effect of ramosetron and dexamethasone for prophylaxis of postoperative nausea and
vomiting in patients undergoing middle ear surgeries. Methods: In a randomized controlled clinical trial, 60 patients were divided into two groups, one receiving ramosetron, one receiving dexamethazone, all patients were subjected to middle ear surgeries. The patients in the Group R received ramosetron (0.3 mg IV) and the patients in Group D received dexamethasone (8 mg IV), Using Bellivelle’s scoring system, the incidence of PONV and its severity during the 24-hour period after surgery were measured and compared. Result: The incidence rates of PONV in dexamethasone group is 89.9%, and with ramosetron group is 29.9%, which showed statistically significance (p - value < 0.0001). The incidence rate of postoperative nausea and vomiting in dexamethasone group is significantly higher than that of ramosetron group. Conclusion: Ramosetron 0.3 mg IV given before induction of anesthesia is an effective means of reducing PONV in middle ear surgeries. Compaed to dexamethasone 8 mg IV ramosetron 0.3 mg IV significantly reduces PONV in the immediate postoperative period. Ramosetron is suitable alternative to dexamethasone in controlling PONV

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Cite this article

 

Kishore Keerthy N, Aneesh Rajan. Comparison of Ramosetron and Dexamethasone for Prophylaxis of Postoperative Nausea and
Vomiting in Patients Undergoing Middle Ear Surgeries. Indian J Anesth Analg. 2020;7(2):500–505.

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Received Accepted Published
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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7220.9

Keywords

Postoperative nausea and vomiting; Dexamethasone; Ramosetron; Middle ear surgeries.

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